Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Name Card
rp00485 picture

Professor Xu, Aimin 徐愛民

Title:
Rosie T T Young Professor in Endocrinology and Metabolism
Professor, Chair of Metabolic Medicine
Professor

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
17118619Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signaling11573632019
 
F-HKU701/17The mechanobiology of obesity900002017
 
C7037-17WConversion of white into brown adipocytes as a therapeutic strategy for obesity-related metabolic and vascular complications74399962017
 
17128115Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes10923832015
 
AoE/M-707/18Institute of Metabolic Medicine496890002018
 
17127518Roles of FGF21 signaling pathways in conferring the beneficial effects of physical exercise on cardiac metabolism and function in diabetic hearts12335762018
 
17114924CUB Domain-containing Protein 1 as a Novel Mediator of Nonalcoholic Steatohepatitis: Molecular Mechanism and Therapeutic Implications15535372024
 
05163506Targeting Neutrophil Serine Proteases for Treatment of Vascular Inflammation and Atherosclerosis11934242017
 
2299101761Development of an Evidence-Based Nutritional Intervention Targeting the Gut Microbiota to Improve Athletic Performance2022
 
HKU 784111MThe Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications12500002011
 
HKU 781309MCharacterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication15000002009
 
HKU 782612MThe adaptor protein APPL1 as a physiological regulator of insulin secretion in pancreatic βcells10100002012
 
HKU 7609/05MAngiopoitein-like protein 4 (ANGPTL4) as a novel therapeutic target for the treatment of insulin resistance and hyperglycemia14580402005
 
HKU 779707MAPPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation12582282007
 
HKU 779608MProtective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention11073062008
 
HKU 7486/04MCharacterization of the receptor and postreceptor events that underlie the anti-atherogenic and anti-diabetic actions of adiponectin14145302004
 
HKU 783010MAPPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?12000002010
 
17121523STAP1 as a Novel Perpetrator of Metabolic Inflammation: Molecular Basis and Pathophysiological Implications 15962002023
 
N_HKU 727/05The use of adiponectin as a biomarker to identify novel anti-diabetic and anti-atherogenic agents from Chinese herbs7840002005
 
GHP/027/05Development of a Suspension Antibody Array-based Multiplex Immunoassay for Early Diagnosis and Therapeutic Monitoring of Diabetes and Cardiovascular Diseases28990452005
 
HKU 7645/06MHypoxia inducible factor 1α as a mediator of obesity-induced chronic inflammation, aberrant production of adipokines, and insulin resistance8435002006
 
HKU4/CRF/10A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention63300002010
 
HKU 2/07CVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention55000002007
 
N_HKU 735/08Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications7120002008
 
CUHK2/CRF/12GPhysical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators10000002012
 
HKU 783413MFibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain8660322013
 
A-HKU705/13The gut microbiota-adipose tissue axis in the pathogenesis of obesity and its related metabolic disorders: molecular mechanism and clinical implications26309762013
 
G_HK708/13Adipocyte fatty acid binding protein as a mediator of obesity-related medical complications858002013
 
17124714Interplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues9577942014
 
17117320The mechano-sensitive ion channel Piezo1 balances the conversion of mesenchymal stem cells to osteoblasts and bone marrow adipocytes11955422020
 
82070860Fibroblast growth factor-21 mediates the effects of exercise intervention on protection against diabetic cardiomyopathy6908002020
 
GHP/138/18SZShenzhen-Hong Kong United Network on Cardiovascular Disease (SHUN-CVD)41369012019
 
MHP/117/22Development and Efficacy Evaluation of Therapeutic Monoclonal Antibodies Targeting Autotaxin18007062023
 
InP/305/15Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications2494102015
 
C7055-14GA Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention87808502014
 
02132836FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes9997362014
 
N_HKU726/14Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance10989112014
 
N/AFrontiers in Immunometabolism6000002015
 
T12-101/23-NSingle-Cell Multi-Omics Study of Atherosclerotic Vascular Disease: Narrowing the Gap Between Bench and Bedside 2023
 
N/AVascular Dysfunction in Obestiy and Diabetes: From Molecular Mechanism to Therapeutic Intervention9600002016
 
03144516FGF21 as a potential mediator for the anti-depressant effects of physical exercise11976082015
 
03143966Deciphering the molecular mechanism of Protein Arginine Methyltransferase (PRMT) 1 in the regulation of hepatic glucose and lipid metabolism9192962015
 
E-HKU703/20Targeting Gut Microbiota for Non-alcoholic Fatty Liver Disease16918432020
 
13143731Activation of uncoupling protein-1 as a potential therapeutic strategy for obesity-induced endothelial dysfunction and atherosclerosis11590102015
 
17166016Fibroblast growth factor-21 as an Autocrine Regulator of Browning and Adaptive Thermogenesis in Subcutaneous Adipose Tissue12477722016
 
N/ADiscovery and Development of Innovative Antibody Drugs for Metabolic and Cardiovascular Diseases37500002020
 
06172446Autotaxin as a potential mediator of obesity-related metabolic complications14969962018
 
08192316Thrombospondin-2 as a potential diagnostic biomarker and therapeutic target of nonalcoholic fatty liver disease14961602020
 
17125317UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy12158402017
 
C4024-16WA multi-disciplinary study on the beneficial effects of PPARD in physical exercise against diabetic vascular complications: cellular crosstalk and energy metabolism10000002016
 
17121819The Single Transmembrane Protein β-klotho as a Novel Regulator of Insulin Secretion in Pancreatic β-cells16848952019
 
07182726Implementation of multi-biomarkers algorithm for detection in Chinese obese individuals with non-alcoholic fatty liver disease14972442019
 
17125022A novel Role of Stanniocalcin-2 in the Regulation of Insulin Secretion from Pancreatic β cells13690532022
 
09201296Branched-chain amino acids mediate the crosstalk between gut microbiome and adipose tissue to induce metabolic inflammation 2022
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
CFS-HKU5Risk of cardiovascular diseases and related disorders in Hong Kong Chinese: Building on the strength of the Hong Kong Cardiovascular Risk Factors Prevalence Study (1995-2018)74995322018
 
T12-705/11Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform337050002011
 
17117724Semaphorin 6B as a novel glucose-lowering hormone to counteract type 2 diabetes: molecular mechanism and clinical implications15586062024
 
13142641Human Prostacyclin Receptors and Endothelial Dysfunction11927362015
 
HKU 7561/05MFat-derived hormone adiponectin as a novel therapy for fatty liver graft injury7189572005
 
HKU 768209MAdipocyte fatty acid binding protein as a novel mediator of obesity-related fatty liver disease7557602009
 
HKU 7590/06MAdipocyte fatty acid binding proteins: new mediators of the metabolic syndrome and coronary atherosclerosis17797002006
 
HKU 777908MMolecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 215192842008
 
06172646Mitochondrial protein coiled-coil-helix-coiled-coil-helix domain 10 (Chchd10) as a novel factor for the treatment of obesity and its related diseases9823962018
 
ITS/048/03Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders22889602003
 
N/AAgeing15000002013
 
17101819Syndecan-4 (Sdc4) as a key regulator of white adipose tissue browning for energy expenditure11133412019
 
05162606Gut-derived flagellin ameliorates diet-induced dyslipidemia by upregulating apolipoprotein-A110529962017
 
HKU 767208MRole of JNK in adipose tissue inflammation, adipokine production and systemic insulin resistance10165062008
 
GHP/079/18SZDevelopment and Preclinical Evaluation of a A-FABP Neutralizing Monoclonal Antibody for Ischemic Stroke Treatment14774582019
 
17123915PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy8603592015
 
HKU 778007MThe potential role of lipocalin-2 as an inflammatory adipokine that links obesity with insulin resistance and metabolic disorders8878632007
 
14151651Fatty Acid Binding Protein 4 (FABP-4) causes articular cartilage degeneration through synovial macrophage polarization8710642017
 
HKU 7404/04MLinking the metabolic syndrome with progressive atherosclerosis: role of fat-derived hormones9393602004
 
07182836Role of the mechano-sensitive ion channel Piezo1 in the regulation of obesity and adaptive thermogenesis: molecular mechanisms and clinical implications14824002019
 
08192146Treatment of obesity by selectively delivery of thyroid hormone to white adipose tissue14995162020
 
17116819Mickey takes on obesity for better gum health11157102019
 
17101118TLR5 controls adaptive thermogenesis by posttranscriptional regulation of UCP17422332018
 
N/AAutocrine functions of adipokines580002003
 
HKU 782212MCharacterization of Intramyocellular Lipids by Magnetic Resonance Diffusion12000002012
 
200711159082Role of adipocyte-fatty acid binding protein (A-FABP) in the development of non-alcoholic steatohepatitis (NASH)1060002007
 
17120022Bone marrow adipose tissue orchestrates hematopoiesis to facilitate type 2 immune response during cold-induced beiging of white adipose tissue11800222022
 
HKU 766812MInterplay between adipocyte fatty acid binding protein and endoplasmic reticulum stress in toxic lipids-induced inflammation in macrophages7500002012
 
17124614The role of FoxO1 in diabetic heart susceptibility to ischemia/reperfusion injury and sensitivity to ischemic postconditioning and its interplay with adiponectin5995352014
 
HKU 7426/03MClinical, genetic and functional studies of two novel fat-derived hormones6240002003
 
06172636Targeting G protein-coupled receptor 110 for the treatment of obesity and non-alcoholic fatty liver disease13992482018
 
200507176039Human ANGPTL4 Gene: Molecular Scanning and Evaluation of Association with Insulin Resistance and Type 2 diabetes in Chinese529202005
 
17110122Treating the metabolic syndrome with a sodium-glucose cotransporter-2 inhibitor: a randomised controlled trial11798052022
 
17105318Neutrophil serine proteases as the endogenous suppressors of white adipose tissue browning and adaptive thermogenesis7756562018
 
201211159084Deciphering the role of lipocalin 13 in obesity and diabetes: from molecular analysis to physiological relevance1177002012
 
05161826Role of Cardiac STAT5A in repeated non-invasive limb ischemic preconditioning-induced cardioprotection in diabetes and its interplay with STAT311794482017
 
HKU 769410MObesity, adipose tissue inflammation and atherosclerosis: role of JNK activation13000002010
 
HKU3/CRF/11RLiver Transplantation Research Centre: A Multidisciplinary Study for Liver Graft Injury42530002011
 
06172596Fatty acid binding protein 4 as a therapeutic target for atherosclerosis by regulating gut microbiota and immunity14339962018
 
17158616PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association.9131522016
 
19201121Targeting peroxisome proliferator-activated receptors in the treatment of Sjögren’s syndrome12220002021
 
HKU 3/CRF/09To Establish a Metabolic Study Center in Hong Kong: Focusing on the liver-derived hormones62000002009
 
06173966The role of bone marrow adipose tissue in glucose tolerance and insulin sensitivity14999002018
 
SEG_HKU02High-Performance Tandem Mass Spectrometry Facility for Functional Proteomics and Metabolomics86000002008
 
04152366Deciphering the molecular mechanism of signal transducing adaptor family member 1 (STAP1) in the regulation of hepatic cholesterol metabolism10598562016
 
HKU5/CRF/08Liver Transplantation Research Centre: A Multidisciplinary Study for Liver Graft Injury55000002008
 
N/AClinical, genetic and functional studies of two novel fat-derived hormones500002003
 
201109176145The role of beta Klotho in regulation of metabolic homeostasis: Molecular Basis and Physiological Implications800002011
 
08193216Metabolomics signature for the prediction of diabetic kidney disease in Chinese patients with type 2 diabetes14938202020
 
03143846Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction.10351082015
 
02132496Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice9155682014
 
17123718Deletion of Telomere-Rap1 increases the susceptibility to myocardial ischemia/reperfusion injury via p53-PGC1α signaling during aging8684632018
 
HKU2/CRF/12RTo Establish a Metabolic Study Centre in Hong Kong: Focusing on the Emerging Metabolic Hormones80000002012
 
HKU 784011MEffects of Adiponectin on Diabetic Heart Sensitivity to Ischemic Postconditioning: Role of STAT-3 activation10100002011
 
01122246Potential anti-tumor and anti-metastasis efficacy of novel Notch inhibitor (PF-03084014) in liver cancer models8500162013
 
HKU 778012MActivation of prostaglandin E receptor 4: a novel anti-inflammatory mechanism that protects against adipose tissue inflammation and obesity-related complications.8500002012
 
HKU 762108MThe role of adiponectin in cardiac allograft survival and immune regulation8654152008
 
HKU 780210MBiomarkers of Obesity-related Cardiometaolic Risks in Chinese6094452010
 
09201676Novel exerkines: relationship with metabolic and cardiovascular outcomes14809572021
 
HKU 7637/05MMacrophage-adipocyte cross-talk in the initiation of obesity-related insulin resistance and type 2 diabetes: role of adiponectin9019572005
 
HKU 767913MAdipocyte fatty acid binding protein (A-FABP) as a potential mediator of cardiac dysfunction and heart failure related to diabetes and obesity7361282013
 
02131906Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis9047362014
 
HKU 766707MExploration of the role of adipocyte fatty acid binding protein in the association of obstructive sleep apnea and metabolic dysfunction9571322007
 
HLCA/M-715/23Leveraging brown adipose tissue to combat elderly stroke3890002023
 
T12-101/23-N Single-Cell Multi-Omics Study of Atherosclerotic Vascular Disease: Narrowing the Gap Between Bench and Bedside 2023
 
T12-202/23-RDysregulated Host - Gut Microbiota Co-Metabolism in Metabolic Associated Fatty Liver Disease2023
 
17126523Elucidating roles of adaptor protein APPL2 in inhibiting adult neurogenesis via affecting mitochondrial function, redox signaling and mitochondrial dynamics in ischemic stroke with hyperglycemia11902642023
 
11221906The potential role of L-Arginine in managing Type 2 Diabetes: from prediction to therapeutic treatment 4612962022
 
17107124β-Klotho as a novel anti-ageing factor by suppressing adipose senescence10574812024
Loading Content...Please Wait!