Neutrophil serine proteases as the endogenous suppressors of white adipose tissue browning and adaptive thermogenesis
Grant Data
Project Title
Neutrophil serine proteases as the endogenous suppressors of white adipose tissue browning and adaptive thermogenesis
Principal Investigator
Professor Hoo, Ruby Lai Chong
(Principal Investigator (PI))
Co-Investigator(s)
Professor Xu Aimin
(Co-Investigator)
Dr Cheng King Yip
(Co-Investigator)
Duration
42
Start Date
2019-01-01
Completion Date
2022-06-30
Amount
775656
Conference Title
Neutrophil serine proteases as the endogenous suppressors of white adipose tissue browning and adaptive thermogenesis
Keywords
adaptive thermogenesis, adipose tissue browning, neutrophil elastase (NE), Obesity, proteinase 3 (PR3)
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17105318
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To investigate the roles of neutrophil in the development of obesity and WAT browning using genetically modified- and high fat diet-induced obese models; 2 To delineate the functional significance of NE and PR3 in the regulation of WAT browning and adaptive thermogenesis in obesity using NE/PR3 knockout mice; 3 To elucidate the underlying molecular mechanisms whereby NE and PR3 control beige adipogenesis.