Deletion of Telomere-Rap1 increases the susceptibility to myocardial ischemia/reperfusion injury via p53-PGC1α signaling during aging

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Grant Data
Project Title
Deletion of Telomere-Rap1 increases the susceptibility to myocardial ischemia/reperfusion injury via p53-PGC1α signaling during aging
Principal Investigator
Dr Xia, Zhengyuan   (Principal Investigator (PI))
Co-Investigator(s)
Professor Huang Yu   (Co-Investigator)
Professor Xu Aimin   (Co-Investigator)
Dr Yan Bin   (Co-Investigator)
Professor Irwin Michael Garnet   (Co-Investigator)
Duration
36
Start Date
2019-01-01
Amount
868463
Conference Title
Deletion of Telomere-Rap1 increases the susceptibility to myocardial ischemia/reperfusion injury via p53-PGC1α signaling during aging
Presentation Title
Keywords
aging, ischemia/reperfusion injury, p53, PGC1α, Rap1
Discipline
Cardiovascular Research,Others - Medicine, Dentistry and Health
Panel
Biology and Medicine (M)
HKU Project Code
17123718
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To investigate whether or not Rap1 deletion increases the susceptibility to myocardial I/RI in aging model. 2 To investigate whether or not Rap1 deletion precipitates cardiac aging and mitochondrial dysfunction in aging model. 3 To determine whether or not Rap1 protects against cardiac mitochondrial defects and myocardial I/RI via p53-PGC1α signaling in aging model.