Roles of FGF21 signaling pathways in conferring the beneficial effects of physical exercise on cardiac metabolism and function in diabetic hearts
Grant Data
Project Title
Roles of FGF21 signaling pathways in conferring the beneficial effects of physical exercise on cardiac metabolism and function in diabetic hearts
Principal Investigator
Professor Xu, Aimin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Xia Zhengyuan
(Co-Investigator)
Duration
42
Start Date
2019-01-01
Completion Date
2022-06-30
Amount
1233576
Conference Title
Roles of FGF21 signaling pathways in conferring the beneficial effects of physical exercise on cardiac metabolism and function in diabetic hearts
Keywords
cardiac dysfunction, lipid metabolism, Metabolic hormones, mitochondrial dysfunction, physical exercise
Discipline
Diabetes/MetabolismCardiovascular Research
Panel
Biology and Medicine (M)
HKU Project Code
17127518
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To further evaluate whether FGF21 signaling is involved in exercise-induced alleviation of metabolic disturbance, insulin resistance and lipotoxicity in diabetic hearts; 2 To investigate whether FGF21 mediates the cardiac protection of exercises via its direct actions in cardiomyocytes or indirect effects in adipose tissues; 3 To interrogate whether cardiac SirT3 is an obligatory downstream signaling molecule of FGF21 mediating the cardio-protective activities of physical exercise