The mechano-sensitive ion channel Piezo1 balances the conversion of mesenchymal stem cells to osteoblasts and bone marrow adipocytes
Grant Data
Project Title
The mechano-sensitive ion channel Piezo1 balances the conversion of mesenchymal stem cells to osteoblasts and bone marrow adipocytes
Principal Investigator
Professor Xu, Aimin
(Principal Investigator (PI))
Duration
42
Start Date
2021-01-01
Amount
1195542
Conference Title
The mechano-sensitive ion channel Piezo1 balances the conversion of mesenchymal stem cells to osteoblasts and bone marrow adipocytes
Keywords
bone marrow adipocyte, insulin sensitivity, mechano-sensitive ion channel, mesenchymal stem cell, osteoblast
Discipline
EndocrinologyDiabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17117320
Grant Type
General Research Fund (GRF)
Funding Year
2020
Status
On-going
Objectives
1 To further characterize the phenotypic changes of PDGFRα-Piezo1 KO mice, and to consolidate that Piezo1 deletion specifically in PDGFRα+ MSCs leads to reduced bone mass and increased marrow adiposity. 2 To interrogate whether Piezo1 in MSCs mediates exercise-induced bone formation, reduction in marrow adipocytes and improvement in systemic insulin sensitivity. 3 To investigate detailed intracellular signaling pathway by which Piezo1 controls the cell fate determination of MSCs. 4 To identify the Piezo1-dependent secretory factors that directs the differentiation of MSCs and function of bone marrow adipocytes.