Role of the mechano-sensitive ion channel Piezo1 in the regulation of obesity and adaptive thermogenesis: molecular mechanisms and clinical implications
Grant Data
Project Title
Role of the mechano-sensitive ion channel Piezo1 in the regulation of obesity and adaptive thermogenesis: molecular mechanisms and clinical implications
Principal Investigator
Dr Wang, Baile
(Principal Investigator (PI))
Co-Investigator(s)
Professor Xu Aimin
(Co-Investigator)
Duration
48
Start Date
2020-04-01
Amount
1482400
Conference Title
Role of the mechano-sensitive ion channel Piezo1 in the regulation of obesity and adaptive thermogenesis: molecular mechanisms and clinical implications
Keywords
adipogenesis, mechano-sensitive, obesity, Piezo1, thermogenesis
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
07182836
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2019
Status
On-going
Objectives
Adipocytes and adipose progenitors are becoming recognized as mechano-sensitive cells, but identity of the mechano-sensors and underlying mechanisms are still obscure. This study aims at exploring the functional role of the mechano-sensitive ion channel Piezo1 in the regulation of adipogenesis, lipid metabolism and activity/formation of thermogenic brown and beige adipocytes.