UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy
Grant Data
Project Title
UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy
Principal Investigator
Professor Xu, Aimin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Hui Xiaoyan
(Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
1215840
Conference Title
UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy
Presentation Title
Keywords
adipokines, adipose tissues, energy expenditure, metabolic diseases, obesity
Discipline
Diabetes/Metabolism,Endocrinology
Panel
Biology and Medicine (M)
HKU Project Code
17125317
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To address whether there exist humoral factors in UCP1-null mice mediating UCP1-independent energy utilization by using parabiosis and co-culture approaches; 2 To characterize the BAT-derived secretory factor(s) that promote remodeling and compensatory energy expenditure in scWAT; 3 To elucidate the molecular mechanisms whereby UCP1 deletion alters production of thermogenic factors in classical BAT; 4 To investigate how altered secretory factors from UCP1-deficient BAT increase mitochondrial number and promote UCP1-independent thermogenic pathways in scWAT.