PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy

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Grant Data
Project Title
PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy
Principal Investigator
Dr Xia, Zhengyuan   (Principal Investigator (PI))
Co-Investigator(s)
Professor Irwin Michael Garnet   (Co-Investigator)
Professor Xu Aimin   (Co-Investigator)
Professor Wang Junwen John   (Co-Investigator)
Dr Yue Jianbo   (Co-Investigator)
Duration
36
Start Date
2015-09-01
Amount
860359
Conference Title
PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy
Presentation Title
Keywords
Autophagy, Caveolin-3, Diabetes, Ischemia
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17123915
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To investigate the status of PKCß2 activation in relation to the severity of the ischemic insult and its impact on both cardiac Cav-3 and autophagy during myocardial IRI 2 To determine the role of hyperglycemia-induced PKCß2 over-activation in diabetic myocardial IRI and its relationship/interplay with Cav-3, exploring their impacts on cardiomyocyte autophagy 3 To determine the role of Cav-3 in diabetic myocardial IRI and its impact on PKCß2 inhibition mediated attenuation of myocardial IRI in diabetes