Branched-chain amino acids mediate the crosstalk between gut microbiome and adipose tissue to induce metabolic inflammation
Grant Data
Project Title
Branched-chain amino acids mediate the crosstalk between gut microbiome and adipose tissue to induce metabolic inflammation
Principal Investigator
Professor Xu, Aimin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Wang Yaokai
(Co-Investigator)
Duration
36
Start Date
2023-01-01
Conference Title
Branched-chain amino acids mediate the crosstalk between gut microbiome and adipose tissue to induce metabolic inflammation
Keywords
BCAAs, Adipose tissue, ADAM17, soluble IL-6 receptor, Insulin resistance
Discipline
Medicine, Dentistry and Health
HKU Project Code
09201296
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2022
Status
On-going
Objectives
Elevated circulating branched-chain amino acids (BCAAs) levels are widely observed in obesity and diabetes. Our study suggested alternations in serum BCAAs concentrations are tightly associated with changes of pro-inflammation cytokines in humans after exercise training. Meanwhile, exercise attenuates pro-inflammation cytokines secretion mainly by downregulating ADAM17 in white adipose tissue (WAT).