Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signaling

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Grant Data
Project Title
Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signaling
Principal Investigator
Professor Xu, Aimin   (Principal Investigator (PI))
Co-Investigator(s)
Professor Irwin Michael Garnet   (Co-Investigator)
Dr Xia Zhengyuan   (Co-Investigator)
Professor Huang Yu   (Co-Investigator)
Duration
36
Start Date
2020-01-01
Completion Date
2022-12-31
Amount
1157363
Conference Title
Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signaling
Keywords
CD36, diabetic cardiomyopathy, EP4, fatty acid metabolism, FOXO1
Discipline
Cardiovascular ResearchDiabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17118619
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To investigate whether EP4 deficiency exacerbates DCM; 2 To confirm whether deficiency of EP4 aggravates DCM through inhibition of FOXO1 in diabetic rodents; 3 To explore whether EP4 protects against DCM through improving FOXO1/CD36-dependent fatty acids metabolism in diabetic rodents.