Fatty acid binding protein 4 as a therapeutic target for atherosclerosis by regulating gut microbiota and immunity
Grant Data
Project Title
Fatty acid binding protein 4 as a therapeutic target for atherosclerosis by regulating gut microbiota and immunity
Principal Investigator
Dr Shu, Lingling
(Principal Investigator (PI))
Co-Investigator(s)
Professor Hoo Ruby Lai Chong
(Co-Investigator)
Professor Xu Aimin
(Co-Investigator)
Duration
54
Start Date
2019-04-01
Amount
1433996
Conference Title
Fatty acid binding protein 4 as a therapeutic target for atherosclerosis by regulating gut microbiota and immunity
Keywords
acid, atherosclerosis, Fatty, immunity, microbiota, therapeutic
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06172596
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
FABP4 is implicated in pathogenesis of atherosclerosis, however the precise mechanisms have not been fully investigated. FABP4 enhances gut permeability and alters gut microbiota composition. Moreover, FABP4 shows the potential to promote the infiltration of immune cells. This study is aim to explore the role and underlying mechanism of FABP4 promotes atherosclerosis through mediating the crosstalk between gut microbiota and immunity, providing substantial evidences targeting FABP4 to treat diet-induced atherosclerosis.