Human ANGPTL4 Gene: Molecular Scanning and Evaluation of Association with Insulin Resistance and Type 2 diabetes in Chinese
Grant Data
Project Title
Human ANGPTL4 Gene: Molecular Scanning and Evaluation of Association with Insulin Resistance and Type 2 diabetes in Chinese
Principal Investigator
Emeritus Professor Lam, Karen Siu Ling
(Principal Investigator (PI))
Co-Investigator(s)
Dr Xu Jianyu
(Co-Investigator)
Professor Xu Aimin
(Co-Investigator)
Duration
18
Start Date
2005-10-01
Amount
52920
Conference Title
Human ANGPTL4 Gene: Molecular Scanning and Evaluation of Association with Insulin Resistance and Type 2 diabetes in Chinese
Presentation Title
Keywords
ANGPTL4, Diabetes, Genetics
Discipline
Endocrinology
HKU Project Code
200507176039
Grant Type
Small Project Funding
Funding Year
2005
Status
Completed
Objectives
The angiopoietin like protein-4 (ANGPTL4) is a hormone, predominantly derived from fat cells, which has been recently shown by our group to decrease blood glucose and hepatic insulin resistance in rodents. The purpose of this project is to determine whether the ANGPTL4 gene plays a significant role in the genetic susceptibility to diabetes and other insulin resistance related traits in humans, using blood and DNA samples collected from on-going cross-sectional and prospective studies. Objectives 1. To systematically search for polymorphisms in the human ANGPTL4 gene in southern Chinese 2. To perform case control association studies of ANGPTL4 polymorphisms and haplotypes with the risk of T2DM, obesity, insulin resistance, and hyperlipidemia 3. To investigate the role of ANGPTL4 polymorphisms and haplotypes in predicting the development of diabetes in a 10- year prospective follow-up study of 600 non-diabetic subjects 4. To determine the role of genetic polymorphisms in regulating circulating ANGPTL4 levels