Syndecan-4 (Sdc4) as a key regulator of white adipose tissue browning for energy expenditure

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Grant Data
Project Title
Syndecan-4 (Sdc4) as a key regulator of white adipose tissue browning for energy expenditure
Principal Investigator
Dr Hoo, Ruby Lai Chong   (Principal Investigator (PI))
Co-Investigator(s)
Professor Xu Aimin   (Co-Investigator)
Duration
42
Start Date
2020-01-01
Amount
1113341
Conference Title
Syndecan-4 (Sdc4) as a key regulator of white adipose tissue browning for energy expenditure
Presentation Title
Keywords
Energy expenditure, Obesity, Sdc4 ectodomain, Syndecan-4, White adipose tissue browning
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17101819
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
On-going
Objectives
1 To determine the functional significance of adipose tissue-Sdc4 in cold-induced thermogenesis and diet-induced obesity using lentivirus-mediated adipose tissue-specific Sdc4 knockdown mice 2 To elucidate the therapeutic potential of AT-specific Sdc4 overexpression or replenishment of Sdc4 ectodomain on diet-induced obesity 3 To investigate the cellular mechanisms whereby Sdc4 mediates iWAT browning and promotes energy expenditure