Deciphering the molecular mechanism of signal transducing adaptor family member 1 (STAP1) in the regulation of hepatic cholesterol metabolism
Grant Data
Project Title
Deciphering the molecular mechanism of signal transducing adaptor family member 1 (STAP1) in the regulation of hepatic cholesterol metabolism
Principal Investigator
Dr Zhong, Ling
(Principal Investigator (PI))
Co-Investigator(s)
Professor Xu Aimin
(Co-Investigator)
Dr Woo Wai Hong Connie
(Co-Investigator)
Dr Chan Chi Ping
(Co-Investigator)
Duration
42
Start Date
2017-08-01
Amount
1059856
Conference Title
Deciphering the molecular mechanism of signal transducing adaptor family member 1 (STAP1) in the regulation of hepatic cholesterol metabolism
Presentation Title
Keywords
B lymphocytes, cardiovascular diseases, cholesterol metabolism, hypercholesterolemia
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
04152366
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
Objectives: Familial hypercholesterolemia (FH) is a very common inherited disorder which characterized by markedly elevated LDLC levels and greatly increased the risk for premature cardiovascular diseases. Previous studies suggested that 60-80% of FH is caused by mutations in three cholesterol homeostasis genes ( LDLR, APOB or PCSK9). Recently, two independent findings provided strong genetic evidence for involvement of STAP1 in regulating cholesterol homeostasis, but the molecular mechanism how a B lymphocyte-specific protein STAP1 regulates cholesterol metabolism is not clear.