TLR5 controls adaptive thermogenesis by posttranscriptional regulation of UCP1
Grant Data
Project Title
TLR5 controls adaptive thermogenesis by posttranscriptional regulation of UCP1
Principal Investigator
Dr Woo, Wai Hong Connie
(Principal Investigator (PI))
Co-Investigator(s)
Dr Wong Chi Ming
(Co-Investigator)
Professor Xu Aimin
(Co-Investigator)
Duration
42
Start Date
2018-09-01
Completion Date
2022-02-28
Amount
742233
Conference Title
TLR5 controls adaptive thermogenesis by posttranscriptional regulation of UCP1
Presentation Title
Keywords
adaptive thermogenesis, Adipose tissue, Posttranscriptional regulation, Toll-like receptor 5, Uncoupling protein-1
Discipline
Molecular Biology,Physiology
Panel
Biology and Medicine (M)
HKU Project Code
17101118
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To validate the dysfunction of adaptive thermogenic response in TLR5-deficient mice; 2 To elucidate the molecular mechanism of how UCP1 expression is regulated by TLR5 in thermogenic adipocytes; and 3 To examine whether TLR5 in adipose tissue macrophages indirectly influence adaptive thermogenesis.