Mitochondrial protein coiled-coil-helix-coiled-coil-helix domain 10 (Chchd10) as a novel factor for the treatment of obesity and its related diseases
Grant Data
Project Title
Mitochondrial protein coiled-coil-helix-coiled-coil-helix domain 10 (Chchd10) as a novel factor for the treatment of obesity and its related diseases
Principal Investigator
Dr Hoo, Ruby Lai Chong
(Principal Investigator (PI))
Co-Investigator(s)
Professor Xu Aimin
(Co-Investigator)
Duration
35
Start Date
2019-06-01
Amount
982396
Conference Title
Mitochondrial protein coiled-coil-helix-coiled-coil-helix domain 10 (Chchd10) as a novel factor for the treatment of obesity and its related diseases
Presentation Title
Keywords
coiled-coil-helix-coiled-coil-helix, diseases, domain, Mitochondrial, obesity, protein
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06172646
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
Completed
Objectives
Disproportional energy intake and expenditure contributes to the development of obesity. Enhancing thermogenesis through activating brown adipose tissue (BAT) and promoting conversion of white to brown adipocytes (browning/beiging) are recognised as an effective strategy to combat obesity. Cold stress is one of the physiological stimulators of white adipose tissue(WAT) browning and BAT activity. Here we aim to identify novel factor and elucidate its mechanism in modulating cold-induced thermogenesis.