The Single Transmembrane Protein β-klotho as a Novel Regulator of Insulin Secretion in Pancreatic β-cells
Grant Data
Project Title
The Single Transmembrane Protein β-klotho as a Novel Regulator of Insulin Secretion in Pancreatic β-cells
Principal Investigator
Professor Xu, Aimin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Cheng King Yip
(Co-Investigator)
Duration
42
Start Date
2020-01-01
Completion Date
2023-06-30
Amount
1684895
Conference Title
The Single Transmembrane Protein β-klotho as a Novel Regulator of Insulin Secretion in Pancreatic β-cells
Keywords
Glucose metabolism, Hormones, Insulin secretion, Metabolic disease, β-cell dysfunction
Discipline
Diabetes/MetabolismEndocrinology
Panel
Biology and Medicine (M)
HKU Project Code
17121819
Grant Type
General Research Fund (GRF)
Funding Year
2019
Status
Completed
Objectives
1 To comprehensively interrogate whether reduced β-klotho expression in pancreatic islets is a causal contributor to defective insulin secretion, β-cell loss, and hyperglycemia in type-2 diabetic mice; 2 To investigate whether β-klotho controls insulin secretion through modulation of glycolysis in pancreatic β-cells of type-2 diabetic mice; 3 To investigate whether the regulatory role of β-Klotho in glycolysis and GSIS is mediated by HIF1/ARNT or other transcription factors in pancreatic β-cells; 4 To elucidate the molecular and structural basis whereby β-Klotho induces HIF1a, glycolysis, and GSIS in pancreatic β-cells.