Role of adipocyte-fatty acid binding protein (A-FABP) in the development of non-alcoholic steatohepatitis (NASH)
Grant Data
Project Title
Role of adipocyte-fatty acid binding protein (A-FABP) in the development of non-alcoholic steatohepatitis (NASH)
Principal Investigator
Emeritus Professor Lam, Karen Siu Ling
(Principal Investigator (PI))
Co-Investigator(s)
Professor Xu Aimin
(Co-Investigator)
Dr Hoo Ruby Lai Chong
(Co-Investigator)
Duration
24
Start Date
2008-04-01
Completion Date
2010-03-31
Amount
106000
Conference Title
Role of adipocyte-fatty acid binding protein (A-FABP) in the development of non-alcoholic steatohepatitis (NASH)
Presentation Title
Keywords
adipocyte fatty acid binding protein, fatty liver, obesity
Discipline
Diabetes/Metabolism
HKU Project Code
200711159082
Grant Type
Seed Fund for PI Research – Basic Research
Funding Year
2007
Status
Completed
Objectives
Major objective: To elucidate the role of A-FABP in the development of non-alcoholic steatohepatitis. The specific objectives are: 1. To investigate whether the enhanced expression of A-FABP in the liver of db/db diabetic mice is mainly attributable to Kupffer cells. 2. To generate adenovirus that over-expresses A-FABP or luciferase (control), and investigate the mechanisms whereby ectopic hepatic expression of A-FABP may lead to the development of NASH including, specifically, whether adenovirus-mediated ectopic expression of A-FABP leads to the activation of major pro-inflammatory pathways, including NF-kappaB and the JNK (c-Jun NH2- terminal kinase) pathways.