Autotaxin as a potential mediator of obesity-related metabolic complications

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Grant Data
Project Title
Autotaxin as a potential mediator of obesity-related metabolic complications
Principal Investigator
Professor Xu, Aimin   (Principal Investigator (PI))
Co-Investigator(s)
Dr Li Huating   (Co-Investigator)
Duration
36
Start Date
2019-07-15
Amount
1496996
Conference Title
Autotaxin as a potential mediator of obesity-related metabolic complications
Presentation Title
Keywords
Autotaxin, complications, mediator, metabolic, obesity-related, potential
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06172446
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2018
Status
On-going
Objectives
Increased production of autotaxin in obese adipose tissue is an important contributor to the development of obesity-related metabolic complications through both its autocrine and endocrine actions. Circulating autotaxin may be an independent predictor for T2D in Chinese. Blocking autotaxin actions with its neutralizing antibodies can alleviate obesity-associated comorbidities. We will test the hypothesis by conducting both clinical and animal studies, and will investigate the molecular and structural basis underlying the metabolic actions of autotaxin.