PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association.

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Grant Data
Project Title
PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association.
Principal Investigator
Dr Xia, Zhengyuan   (Principal Investigator (PI))
Co-Investigator(s)
Professor Irwin Michael Garnet   (Co-Investigator)
Professor Xu Aimin   (Co-Investigator)
Professor Huang Yu   (Co-Investigator)
Duration
36
Start Date
2017-01-01
Amount
913152
Conference Title
PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association.
Presentation Title
Keywords
Caveolin-3, Diabetes, Ischemic postconditioning, Myocardial ischemia, PKC-ϵ
Discipline
Cardiovascular Research,Diabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17158616
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To define the role of PKCε in mediating diabetic hearts sensitivity to myocardial IRI and its impact on Cav3 2 To determine if PKCε over-activation is responsible for the loss of IPostC cardioprotection in diabetic hearts and to investigate its impact on adiponectin cardioprotective signaling (Cav3/AdipoR1) in diabetes 3 To explore the effects and mechanisms of PKCε inhibition on adiponectin supplementation mediated restoration of IPostC cardioprotection in long term diabetes