HKU Scholars Hub: Project

APPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation

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Grant Data

Project Title

APPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation

Principal Investigator

Professor Xu, Aimin (Principal Investigator (PI))

Co-Investigator(s)

Professor Wang Yu (Co-Investigator)

Professor Chung Sookja Kim (Co-Investigator)

Professor Huang Yu (Co-Investigator)

Duration

Start Date

2008-01-01

Amount

1258228

Conference Title

APPL1 as a novel modulator of endothelial nitric oxide production and endothelium-dependent vasodilation

Presentation Title

Keywords

atherosclerosis, diabetes, phosphorylation, proteomics, vasodilation

Discipline

Signal Transduction,Endocrinology

HKU Project Code

HKU 779707M

Grant Type

General Research Fund (GRF)

Funding Year

2007

Status

Completed

All Publications

Title	Author(s)	Issue Date
A gold(III) porphyrin complex with antitumor properties targets the Wnt/β-catenin pathway Journal:Cancer Research	Chow, KHM Sun, RWY Lam, JBB Li, CKL Xu, A Ma, DL Abagyan, R Wang, Y Che, CM	2010
APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice Journal:Cell Metabolism	Cheng, KKY Iglesias, MA Lam, KSL Wang, Y Sweeney, G Zhu, W Vanhoutte, PM Kraegen, EW Xu, A	2009
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice Journal:Diabetes	Wang, Y Cheng, KKY Lam, KSL Wu, D Wang, Y Huang, Y Vanhoutte, PM Sweeney, G Li, Y Xu, A	2011
Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway Journal:Diabetes	Chang, J Li, Y Huang, Y Lam, KSL Hoo, RLC Wong, WT Cheng, KKY Wang, Y Vanhoutte, PM Xu, A	2010
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities Journal:PLoS ONE	Lam, JBB Chow, KHM Xu, A Lam, KSL Liu, J Wong, NS Moon, RT Shepard, PR Cooper, GJS Wang, Y	2009