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  Patent History
  • Application
    US 10/722349 2003-11-24
  • Granted
    US 7132271 2006-11-07
  Patent Family
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granted patent: Methods for enhancing the production of viral vaccines in cell culture

TitleMethods for enhancing the production of viral vaccines in cell culture
Granted PatentUS 7132271
Granted Date2006-11-07
Priority Date2003-11-24 US 10/722349
2000-12-13 US 09/736748
1998-08-20 US 09/137661
1996-08-21 US 08/700198
2000-12-13 US 09/737126
1998-07-09 US 09/113016
1995-08-22 US 08/002621P
Inventors
Lau, ASY
Issue Date2006
Citation
US Patent US 7132271. Washington, DC: US Patent and Trademark Office (USPTO), 2006 How to Cite?
AbstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/177038
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:59Z-
dc.date.available2012-11-30T08:38:59Z-
dc.date.issued2006-
dc.identifier.citationUS Patent US 7132271. Washington, DC: US Patent and Trademark Office (USPTO), 2006en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177038-
dc.description.abstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.en_HK
dc.relation.isreferencedbyWO 2009023360 (A2) 2009-02-19en_HK
dc.relation.isreferencedbyWO 2009023360 (A3) 2009-08-20en_HK
dc.titleMethods for enhancing the production of viral vaccines in cell cultureen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLau, ASYen_HK
patents.identifier.applicationUS 10/722349en_HK
patents.identifier.grantedUS 7132271en_HK
patents.description.assigneeUNIV CALIFORNIA [US]en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.granted2006-11-07en_HK
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patents.date.application2003-11-24en_HK
patents.date.priority2003-11-24 US 10/722349en_HK
patents.date.priority2000-12-13 US 09/736748en_HK
patents.date.priority1998-08-20 US 09/137661en_HK
patents.date.priority1996-08-21 US 08/700198en_HK
patents.date.priority2000-12-13 US 09/737126en_HK
patents.date.priority1998-07-09 US 09/113016en_HK
patents.date.priority1995-08-22 US 08/002621Pen_HK
patents.description.ccUSen_HK
patents.relation.familyAT 289348 (T) 2005-03-15en_HK
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patents.relation.familyUS 6489144 (B1) 2002-12-03en_HK
patents.relation.familyUS 2001001290 (A1) 2001-05-17en_HK
patents.relation.familyUS 6673591 (B2) 2004-01-06en_HK
patents.relation.familyUS 2001001709 (A1) 2001-05-24en_HK
patents.relation.familyUS 6686190 (B2) 2004-02-03en_HK
patents.relation.familyUS 2001055791 (A1) 2001-12-27en_HK
patents.relation.familyUS 6855519 (B2) 2005-02-15en_HK
patents.relation.familyUS 2004157310 (A1) 2004-08-12en_HK
patents.relation.familyUS 7132271 (B2) 2006-11-07en_HK
patents.relation.familyUS 2004219642 (A1) 2004-11-04en_HK
patents.relation.familyWO 9708292 (A1) 1997-03-06en_HK
patents.relation.familyWO 9708324 (A1) 1997-03-06en_HK
patents.description.kindB2en_HK
patents.typePatent_granteden_HK

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