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Patent History
- ApplicationCN 19961097751 1996-08-22
- PublicationCN 1200148 1998-11-25
Patent Family
- AT 289348 (T) 2005-03-15
- AU 6860896 (A) 1997-03-19
- AU 707130 (B2) 1999-07-01
- AU 6857696 (A) 1997-03-19
- BR 9610550 (A) 1999-07-06
- CA 2229163 (A1) 1997-03-06
- CA 2229405 (A1) 1997-03-06
- CN 1200148 (A) 1998-11-25
- CN 1161469 (C) 2004-08-11
- DE 69634360 (T2) 2005-12-29
- EP 0846160 (A1) 1998-06-10
- EP 0846174 (A1) 1998-06-10
- JP H11511324 (A) 1999-10-05
- JP 3432519 (B2) 2003-08-04
- JP H11514344 (A) 1999-12-07
- JP 4267693 (B2) 2009-05-27
- MX 9801423 (A) 1998-05-31
- US 5840565 (A) 1998-11-24
- US 6159712 (A) 2000-12-12
- US 6489144 (B1) 2002-12-03
- US 2001001290 (A1) 2001-05-17
- US 6673591 (B2) 2004-01-06
- US 2001001709 (A1) 2001-05-24
- US 6686190 (B2) 2004-02-03
- US 2001055791 (A1) 2001-12-27
- US 6855519 (B2) 2005-02-15
- US 2004157310 (A1) 2004-08-12
- US 7132271 (B2) 2006-11-07
- US 2004219642 (A1) 2004-11-04
- WO 9708292 (A1) 1997-03-06
- WO 9708324 (A1) 1997-03-06
Supplementary
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Citations:
- Appears in Collections:
published patent: Methods for enhancing the production of viral vaccines in cell culture by interferon suppression
| Title | Methods for enhancing the production of viral vaccines in cell culture by interferon suppression |
|---|---|
| Priority Date | 1995-08-22 US 08/002621P |
| Inventors | |
| Issue Date | 1998 |
| Citation | China Published Patent Application CN 1200148. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 1998 How to Cite? |
| Abstract | Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines. |
| Persistent Identifier | http://hdl.handle.net/10722/176646 |
| DC Field | Value | Language |
|---|---|---|
| dc.date.accessioned | 2012-11-30T08:38:18Z | - |
| dc.date.available | 2012-11-30T08:38:18Z | - |
| dc.date.issued | 1998 | - |
| dc.identifier.citation | China Published Patent Application CN 1200148. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 1998 | en_HK |
| dc.identifier.uri | http://hdl.handle.net/10722/176646 | - |
| dc.description.abstract | Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines. | en_HK |
| dc.title | Methods for enhancing the production of viral vaccines in cell culture by interferon suppression | en_HK |
| dc.type | Patent | en_US |
| dc.description.nature | published_or_final_version | - |
| dc.contributor.inventor | Lau, ASY | en_HK |
| patents.identifier.application | CN 19961097751 | en_HK |
| patents.description.assignee | UNIV CALIFORNIA [US] | en_HK |
| patents.description.country | China, PRC | en_HK |
| patents.date.publication | 1998-11-25 | en_HK |
| patents.date.application | 1996-08-22 | en_HK |
| patents.date.priority | 1995-08-22 US 08/002621P | en_HK |
| patents.description.cc | CN | en_HK |
| patents.identifier.publication | CN 1200148 | en_HK |
| patents.relation.family | AT 289348 (T) 2005-03-15 | en_HK |
| patents.relation.family | AU 6860896 (A) 1997-03-19 | en_HK |
| patents.relation.family | AU 707130 (B2) 1999-07-01 | en_HK |
| patents.relation.family | AU 6857696 (A) 1997-03-19 | en_HK |
| patents.relation.family | BR 9610550 (A) 1999-07-06 | en_HK |
| patents.relation.family | CA 2229163 (A1) 1997-03-06 | en_HK |
| patents.relation.family | CA 2229405 (A1) 1997-03-06 | en_HK |
| patents.relation.family | CN 1200148 (A) 1998-11-25 | en_HK |
| patents.relation.family | CN 1161469 (C) 2004-08-11 | en_HK |
| patents.relation.family | DE 69634360 (T2) 2005-12-29 | en_HK |
| patents.relation.family | EP 0846160 (A1) 1998-06-10 | en_HK |
| patents.relation.family | EP 0846174 (A1) 1998-06-10 | en_HK |
| patents.relation.family | JP H11511324 (A) 1999-10-05 | en_HK |
| patents.relation.family | JP 3432519 (B2) 2003-08-04 | en_HK |
| patents.relation.family | JP H11514344 (A) 1999-12-07 | en_HK |
| patents.relation.family | JP 4267693 (B2) 2009-05-27 | en_HK |
| patents.relation.family | MX 9801423 (A) 1998-05-31 | en_HK |
| patents.relation.family | US 5840565 (A) 1998-11-24 | en_HK |
| patents.relation.family | US 6159712 (A) 2000-12-12 | en_HK |
| patents.relation.family | US 6489144 (B1) 2002-12-03 | en_HK |
| patents.relation.family | US 2001001290 (A1) 2001-05-17 | en_HK |
| patents.relation.family | US 6673591 (B2) 2004-01-06 | en_HK |
| patents.relation.family | US 2001001709 (A1) 2001-05-24 | en_HK |
| patents.relation.family | US 6686190 (B2) 2004-02-03 | en_HK |
| patents.relation.family | US 2001055791 (A1) 2001-12-27 | en_HK |
| patents.relation.family | US 6855519 (B2) 2005-02-15 | en_HK |
| patents.relation.family | US 2004157310 (A1) 2004-08-12 | en_HK |
| patents.relation.family | US 7132271 (B2) 2006-11-07 | en_HK |
| patents.relation.family | US 2004219642 (A1) 2004-11-04 | en_HK |
| patents.relation.family | WO 9708292 (A1) 1997-03-06 | en_HK |
| patents.relation.family | WO 9708324 (A1) 1997-03-06 | en_HK |
| patents.description.kind | A | en_HK |
| patents.type | Patent_published | en_HK |