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Patent History
- ApplicationBR 19960010550 1996-08-22
- PublicationBR 9610550 1999-07-06
Patent Family
- AT 289348 (T) 2005-03-15
- AU 6860896 (A) 1997-03-19
- AU 707130 (B2) 1999-07-01
- AU 6857696 (A) 1997-03-19
- BR 9610550 (A) 1999-07-06
- CA 2229163 (A1) 1997-03-06
- CA 2229405 (A1) 1997-03-06
- CN 1200148 (A) 1998-11-25
- CN 1161469 (C) 2004-08-11
- DE 69634360 (T2) 2005-12-29
- EP 0846160 (A1) 1998-06-10
- EP 0846174 (A1) 1998-06-10
- JP H11511324 (A) 1999-10-05
- JP 3432519 (B2) 2003-08-04
- JP H11514344 (A) 1999-12-07
- JP 4267693 (B2) 2009-05-27
- MX 9801423 (A) 1998-05-31
- US 5840565 (A) 1998-11-24
- US 6159712 (A) 2000-12-12
- US 6489144 (B1) 2002-12-03
- US 2001001290 (A1) 2001-05-17
- US 6673591 (B2) 2004-01-06
- US 2001001709 (A1) 2001-05-24
- US 6686190 (B2) 2004-02-03
- US 2001055791 (A1) 2001-12-27
- US 6855519 (B2) 2005-02-15
- US 2004157310 (A1) 2004-08-12
- US 7132271 (B2) 2006-11-07
- US 2004219642 (A1) 2004-11-04
- WO 9708292 (A1) 1997-03-06
- WO 9708324 (A1) 1997-03-06
Supplementary
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Citations:
- Appears in Collections:
published patent: METHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION
| Title | METHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION |
|---|---|
| Priority Date | 1995-08-22 US 08/002621P 1996-08-22 PCT/US1996013745 |
| Inventors | |
| Issue Date | 1999 |
| Citation | Brazil Published Patent Application BR 9610550. Brazil: Brazil Patent Office, 1999 How to Cite? |
| Abstract | Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines. |
| Persistent Identifier | http://hdl.handle.net/10722/176563 |
| DC Field | Value | Language |
|---|---|---|
| dc.date.accessioned | 2012-11-30T08:38:07Z | - |
| dc.date.available | 2012-11-30T08:38:07Z | - |
| dc.date.issued | 1999 | - |
| dc.identifier.citation | Brazil Published Patent Application BR 9610550. Brazil: Brazil Patent Office, 1999 | en_HK |
| dc.identifier.uri | http://hdl.handle.net/10722/176563 | - |
| dc.description.abstract | Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines. | en_HK |
| dc.title | METHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION | en_HK |
| dc.type | Patent | en_US |
| dc.contributor.inventor | Lau, ASY | en_HK |
| patents.identifier.application | BR 19960010550 | en_HK |
| patents.description.assignee | UNIV CALIFORNIA [US] | en_HK |
| patents.description.country | Brazil | en_HK |
| patents.date.publication | 1999-07-06 | en_HK |
| patents.date.application | 1996-08-22 | en_HK |
| patents.date.priority | 1995-08-22 US 08/002621P | en_HK |
| patents.date.priority | 1996-08-22 PCT/US1996013745 | en_HK |
| patents.description.cc | BR | en_HK |
| patents.identifier.publication | BR 9610550 | en_HK |
| patents.relation.family | AT 289348 (T) 2005-03-15 | en_HK |
| patents.relation.family | AU 6860896 (A) 1997-03-19 | en_HK |
| patents.relation.family | AU 707130 (B2) 1999-07-01 | en_HK |
| patents.relation.family | AU 6857696 (A) 1997-03-19 | en_HK |
| patents.relation.family | BR 9610550 (A) 1999-07-06 | en_HK |
| patents.relation.family | CA 2229163 (A1) 1997-03-06 | en_HK |
| patents.relation.family | CA 2229405 (A1) 1997-03-06 | en_HK |
| patents.relation.family | CN 1200148 (A) 1998-11-25 | en_HK |
| patents.relation.family | CN 1161469 (C) 2004-08-11 | en_HK |
| patents.relation.family | DE 69634360 (T2) 2005-12-29 | en_HK |
| patents.relation.family | EP 0846160 (A1) 1998-06-10 | en_HK |
| patents.relation.family | EP 0846174 (A1) 1998-06-10 | en_HK |
| patents.relation.family | JP H11511324 (A) 1999-10-05 | en_HK |
| patents.relation.family | JP 3432519 (B2) 2003-08-04 | en_HK |
| patents.relation.family | JP H11514344 (A) 1999-12-07 | en_HK |
| patents.relation.family | JP 4267693 (B2) 2009-05-27 | en_HK |
| patents.relation.family | MX 9801423 (A) 1998-05-31 | en_HK |
| patents.relation.family | US 5840565 (A) 1998-11-24 | en_HK |
| patents.relation.family | US 6159712 (A) 2000-12-12 | en_HK |
| patents.relation.family | US 6489144 (B1) 2002-12-03 | en_HK |
| patents.relation.family | US 2001001290 (A1) 2001-05-17 | en_HK |
| patents.relation.family | US 6673591 (B2) 2004-01-06 | en_HK |
| patents.relation.family | US 2001001709 (A1) 2001-05-24 | en_HK |
| patents.relation.family | US 6686190 (B2) 2004-02-03 | en_HK |
| patents.relation.family | US 2001055791 (A1) 2001-12-27 | en_HK |
| patents.relation.family | US 6855519 (B2) 2005-02-15 | en_HK |
| patents.relation.family | US 2004157310 (A1) 2004-08-12 | en_HK |
| patents.relation.family | US 7132271 (B2) 2006-11-07 | en_HK |
| patents.relation.family | US 2004219642 (A1) 2004-11-04 | en_HK |
| patents.relation.family | WO 9708292 (A1) 1997-03-06 | en_HK |
| patents.relation.family | WO 9708324 (A1) 1997-03-06 | en_HK |
| patents.description.kind | A | en_HK |
| patents.type | Patent_published | en_HK |