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  Patent History
  • Application
    EP 19960929066 1996-08-22
  • Publication
    EP 0846160 1998-06-10
  Patent Family
Supplementary

published patent: METHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION

TitleMETHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION
Priority Date1996-08-22 PCT/US1996013745
1995-08-22 US 08/002621P
Inventors
Lau, ASY
Issue Date1998
Citation
EP Published Patent application EP 0846160. European Patent Office (EPO), Escapenet, 1998 How to Cite?
AbstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/176722
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:24Z-
dc.date.available2012-11-30T08:38:24Z-
dc.date.issued1998-
dc.identifier.citationEP Published Patent application EP 0846160. European Patent Office (EPO), Escapenet, 1998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176722-
dc.description.abstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.en_HK
dc.titleMETHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorLau, ASYen_HK
patents.identifier.applicationEP 19960929066en_HK
patents.description.assigneeUNIV CALIFORNIA [US]en_HK
patents.description.countryEuropean Patent Officeen_HK
patents.date.publication1998-06-10en_HK
dc.relation.referencesWO 9320188 (A1) 1993-10-14en_HK
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patents.date.application1996-08-22en_HK
patents.date.priority1996-08-22 PCT/US1996013745en_HK
patents.date.priority1995-08-22 US 08/002621Pen_HK
patents.description.ccEPen_HK
patents.identifier.publicationEP 0846160en_HK
patents.relation.familyAT 289348 (T) 2005-03-15en_HK
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patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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