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  Patent History
  • Application
    US 09/737126 2000-12-13
  • Granted
    US 6686190 2004-02-03
  Patent Family
Supplementary

granted patent: Methods for enhancing the production of viral vaccines in cell culture

TitleMethods for enhancing the production of viral vaccines in cell culture
Granted PatentUS 6686190
Granted Date2004-02-03
Priority Date2000-12-13 US 09/737126
1998-07-09 US 09/113016
1996-08-21 US 08/700198
1995-08-22 US 08/002621P
Inventors
Lau, ASY
Issue Date2004
Citation
US Patent US 6686190. Washington, DC: US Patent and Trademark Office (USPTO), 2004 How to Cite?
AbstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/177032
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:58Z-
dc.date.available2012-11-30T08:38:58Z-
dc.date.issued2004-
dc.identifier.citationUS Patent US 6686190. Washington, DC: US Patent and Trademark Office (USPTO), 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177032-
dc.description.abstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.en_HK
dc.relation.isreferencedbyUS 8192973 (B2) 2012-06-05en_HK
dc.relation.isreferencedbyUS 2011071073 (A1) 2011-03-24en_HK
dc.relation.isreferencedbyUS 8030046 (B2) 2011-10-04en_HK
dc.relation.isreferencedbyUS 2009291074 (A1) 2009-11-26en_HK
dc.titleMethods for enhancing the production of viral vaccines in cell cultureen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLau, ASYen_HK
patents.identifier.applicationUS 09/737126en_HK
patents.identifier.grantedUS 6686190en_HK
patents.description.assigneeUNIV CALIFORNIA [US]en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.granted2004-02-03en_HK
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patents.date.application2000-12-13en_HK
patents.date.priority2000-12-13 US 09/737126en_HK
patents.date.priority1998-07-09 US 09/113016en_HK
patents.date.priority1996-08-21 US 08/700198en_HK
patents.date.priority1995-08-22 US 08/002621Pen_HK
patents.description.ccUSen_HK
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patents.relation.familyUS 2001055791 (A1) 2001-12-27en_HK
patents.relation.familyUS 6855519 (B2) 2005-02-15en_HK
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patents.description.kindB2en_HK
patents.typePatent_granteden_HK

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