Granted Patent: Methods For The Identification Of Inhibitors Of Asparagine Synthase As Antibiotics

File Download
Patent History
Supplementary

  • Basic View
  • Metadata View
  • XML View
TitleMethods For The Identification Of Inhibitors Of Asparagine Synthase As Antibiotics
Granted PatentUS 6852484
Granted Date2005-02-08
Priority Date2001-12-10 US 09/012991
InventorsLo, CSC
Montenegro-Chamorro, MV
Frank, S
Darveaux, B
Mahanty, S
Heiniger, R
Skalchunes, A
Pan, H
Tarper, R
Shuster, J
Tanzer, MM
Hamer, L
Adachi, K
DeZwaan, TM
CitationUS Patent 6852484. Washington, DC: US Patent and Trademark Office (USPTO), 2005 [How to Cite?]
AbstractThe Present Inventors Have Discovered That Asparagine Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Asparagine Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Asparagine Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit Asparagine Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.
ReferencesUS 4920109 (A) 1990-04-24

US 4920111 (A) 1990-04-24

US 4920112 (A) 1990-04-24

US 4920113 (A) 1990-04-24

US 4921844 (A) 1990-05-01

US 5976848 (A) 1999-11-02

US 6074830 (A) 2000-06-13
DC Field
Value
dc.contributor.inventorLo, CSC
dc.contributor.inventorMontenegro-Chamorro, MV
dc.contributor.inventorFrank, S
dc.contributor.inventorDarveaux, B
dc.contributor.inventorMahanty, S
dc.contributor.inventorHeiniger, R
dc.contributor.inventorSkalchunes, A
dc.contributor.inventorPan, H
dc.contributor.inventorTarper, R
dc.contributor.inventorShuster, J
dc.contributor.inventorTanzer, MM
dc.contributor.inventorHamer, L
dc.contributor.inventorAdachi, K
dc.contributor.inventorDeZwaan, TM
dc.date.accessioned2007-10-30T06:32:44Z
patents.date.application2001-12-10
dc.date.available2007-10-30T06:32:44Z
patents.date.granted2005-02-08
patents.date.priority2001-12-10 US 09/012991
patents.date.publication2003-10-02
dc.description.abstractThe Present Inventors Have Discovered That Asparagine Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Asparagine Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Asparagine Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit Asparagine Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.
patents.description.assigneeIcoria Inc [Us]
patents.description.ccUS
patents.description.countryUnited States of America
patents.description.kindB2
dc.description.naturepublished_or_final_version
dc.format.extent1776177 bytes
dc.format.extent2788 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
patents.identifier.applicationUS 09/012991
dc.identifier.citationUS Patent 6852484. Washington, DC: US Patent and Trademark Office (USPTO), 2005 [How to Cite?]
patents.identifier.grantedUS 6852484
patents.identifier.publicationUS 20030186837
dc.identifier.urihttp://hdl.handle.net/10722/45689
dc.languageeng
patents.relation.familyAU 2002363978 (A1) 2003-06-23
patents.relation.familyCA 2469695 (A1) 2003-06-19
patents.relation.familyEP 1461460 (A2) 2004-09-29
patents.relation.familyJP 2005524390 (A) 2005-08-18
patents.relation.familyUS 2003124642 (A1) 2003-07-03
patents.relation.familyUS 6689578 (B2) 2004-02-10
patents.relation.familyUS 2003143657 (A1) 2003-07-31
patents.relation.familyUS 6733963 (B2) 2004-05-11
patents.relation.familyUS 2003148412 (A1) 2003-08-07
patents.relation.familyUS 6740498 (B2) 2004-05-25
patents.relation.familyUS 2003108979 (A1) 2003-06-12
patents.relation.familyUS 6806060 (B2) 2004-10-19
patents.relation.familyUS 2003186837 (A1) 2003-10-02
patents.relation.familyUS 6852484 (B2) 2005-02-08
patents.relation.familyWO 03050310 (A2) 2003-06-19
dc.relation.referencesUS 4920109 (A) 1990-04-24
dc.relation.referencesUS 4920111 (A) 1990-04-24
dc.relation.referencesUS 4920112 (A) 1990-04-24
dc.relation.referencesUS 4920113 (A) 1990-04-24
dc.relation.referencesUS 4921844 (A) 1990-05-01
dc.relation.referencesUS 5976848 (A) 1999-11-02
dc.relation.referencesUS 6074830 (A) 2000-06-13
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
dc.titleMethods For The Identification Of Inhibitors Of Asparagine Synthase As Antibiotics
dc.typePatent
patents.typePatent_granted