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  Patent History
  • Application
    US 09/012991 2001-12-10
  • Publication
    US 2003186837 2003-10-02
  Patent Family
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published patent: Methods for the identification of inhibitors of asparagine synthase as antibiotics

TitleMethods for the identification of inhibitors of asparagine synthase as antibiotics
Priority Date2001-12-10 US 09/012991
Inventors
Lo, CSCFrank SherylDarveaux BlaiseMahanty SanjoyHeiniger RyanSkalchunes AmyPan HuaqinTarper RexShuster JeffreyTanzer Matthew MHamer LisbethAdachi KiichiDezwaan Todd M
Issue Date2003
Citation
US Published patent application US 2003186837. Washington, DC: US Patent and Trademark Office (USPTO), 2003 How to Cite?
AbstractThe present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Persistent Identifierhttp://hdl.handle.net/10722/176848

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:35Z-
dc.date.available2012-11-30T08:38:35Z-
dc.date.issued2003-
dc.identifier.citationUS Published patent application US 2003186837. Washington, DC: US Patent and Trademark Office (USPTO), 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176848-
dc.description.abstractThe present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Asparagine Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.en_HK
dc.titleMethods for the identification of inhibitors of asparagine synthase as antibioticsen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLo, CSCen_HK
dc.contributor.inventorFrank Sherylen_HK
dc.contributor.inventorDarveaux Blaiseen_HK
dc.contributor.inventorMahanty Sanjoyen_HK
dc.contributor.inventorHeiniger Ryanen_HK
dc.contributor.inventorSkalchunes Amyen_HK
dc.contributor.inventorPan Huaqinen_HK
dc.contributor.inventorTarper Rexen_HK
dc.contributor.inventorShuster Jeffreyen_HK
dc.contributor.inventorTanzer Matthew Men_HK
dc.contributor.inventorHamer Lisbethen_HK
dc.contributor.inventorAdachi Kiichien_HK
dc.contributor.inventorDezwaan Todd Men_HK
patents.identifier.applicationUS 09/012991en_HK
patents.description.assigneeLO SZE-CHUNG, ; MONTENEGRO-CHAMORRO MARIA VICTORIA, ; FRANK SHERYL, ; DARVEAUX BLAISE, ; MAHANTY SANJOY, ; HEINIGER RYAN, ; SKALCHUNES AMY, ; PAN HUAQIN, ; TARPER REX, ; SHUSTER JEFFREY, ; TANZER MATTHEW M, ; HAMER LISBETH, ; ADACHI KIICHI, ; DEZWAAN TODD M, ; ICORIA, INCen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2003-10-02en_HK
patents.date.application2001-12-10en_HK
patents.date.priority2001-12-10 US 09/012991en_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2003186837en_HK
patents.relation.familyAU 2002363978 (A1) 2003-06-23en_HK
patents.relation.familyCA 2469695 (A1) 2003-06-19en_HK
patents.relation.familyEP 1461460 (A2) 2004-09-29en_HK
patents.relation.familyJP 2005524390 (A) 2005-08-18en_HK
patents.relation.familyUS 2003124642 (A1) 2003-07-03en_HK
patents.relation.familyUS 6689578 (B2) 2004-02-10en_HK
patents.relation.familyUS 2003143657 (A1) 2003-07-31en_HK
patents.relation.familyUS 6733963 (B2) 2004-05-11en_HK
patents.relation.familyUS 2003148412 (A1) 2003-08-07en_HK
patents.relation.familyUS 6740498 (B2) 2004-05-25en_HK
patents.relation.familyUS 2003108979 (A1) 2003-06-12en_HK
patents.relation.familyUS 6806060 (B2) 2004-10-19en_HK
patents.relation.familyUS 2003186837 (A1) 2003-10-02en_HK
patents.relation.familyUS 6852484 (B2) 2005-02-08en_HK
patents.relation.familyWO 03050310 (A2) 2003-06-19en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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