published patent: METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS

TitleMETHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICS
Priority Date2002-12-06 PCT/US2002039286
2001-12-06 US 09/007022
2001-12-06 US 09/010084
2001-12-06 US 09/010227
2001-12-07 US 09/011106
2001-12-10 US 09/012991
Inventors
Issue Date2004
Citation
EP Published Patent application EP 1461460. European Patent Office (EPO), Escapenet, 2004 How to Cite?
AbstractThe present inventors have discovered that Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase are essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase or Threonine synthase gene expression in fungi results in no signs of successful infection or lesion. Thus, Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase can be used as targets for the identification of antibiotics, preferably antifungals.; Accordingly, the present inventio provides methods for the identification of compounds that inhibit Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-hosphatase, 3-Isopropylmalate dehydratase or Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Persistent Identifierhttp://hdl.handle.net/10722/176734

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:25Z-
dc.date.available2012-11-30T08:38:25Z-
dc.date.issued2004-
dc.identifier.citationEP Published Patent application EP 1461460. European Patent Office (EPO), Escapenet, 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176734-
dc.description.abstractThe present inventors have discovered that Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase are essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase or Threonine synthase gene expression in fungi results in no signs of successful infection or lesion. Thus, Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-phosphatase, 3-Isopropylmalate dehydratase and Threonine synthase can be used as targets for the identification of antibiotics, preferably antifungals.; Accordingly, the present inventio provides methods for the identification of compounds that inhibit Asparagine Synthase, 5-Aminolevulinate synthase, histidinol-hosphatase, 3-Isopropylmalate dehydratase or Threonine synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR THE IDENTIFICATION OF INHIBITORS OF ASPARAGINE SYNTHASE, 5-AMINOLEVULINATE SYNTHASE, HISTIDINOL-PHOSPHATASE, 3-ISOPROPYLMALATE AND THREONINE SYNTHASE AS ANTIBIOTICSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorShuster, Jeffrey, Ren_HK
dc.contributor.inventorTanzer, Matthew, Men_HK
dc.contributor.inventorHamer, Lisbethen_HK
dc.contributor.inventorAdachi, Kiichien_HK
dc.contributor.inventorDezwaan, Todd, Men_HK
dc.contributor.inventorLo, CSCen_HK
dc.contributor.inventorFrank, Sheryl, Aen_HK
dc.contributor.inventorDarveaux, Blaise, Aen_HK
dc.contributor.inventorMahanty, Sanjoy, Ken_HK
dc.contributor.inventorHeiniger, Ryan, Wen_HK
dc.contributor.inventorSkalchunes, Amy, Ren_HK
dc.contributor.inventorPan, Huaquinen_HK
dc.contributor.inventorTarpey, Rexen_HK
patents.identifier.applicationEP 20020798496en_HK
patents.description.assigneePARADIGM GENETICS INC [US]en_HK
patents.description.countryEuropean Patent Officeen_HK
patents.date.publication2004-09-29en_HK
patents.date.application2002-12-06en_HK
patents.date.priority2002-12-06 PCT/US2002039286en_HK
patents.date.priority2001-12-06 US 09/007022en_HK
patents.date.priority2001-12-06 US 09/010084en_HK
patents.date.priority2001-12-06 US 09/010227en_HK
patents.date.priority2001-12-07 US 09/011106en_HK
patents.date.priority2001-12-10 US 09/012991en_HK
patents.description.ccEPen_HK
patents.identifier.publicationEP 1461460en_HK
patents.relation.familyAU 2002363978 (A1) 2003-06-23en_HK
patents.relation.familyCA 2469695 (A1) 2003-06-19en_HK
patents.relation.familyEP 1461460 (A2) 2004-09-29en_HK
patents.relation.familyJP 2005524390 (A) 2005-08-18en_HK
patents.relation.familyUS 2003124642 (A1) 2003-07-03en_HK
patents.relation.familyUS 6689578 (B2) 2004-02-10en_HK
patents.relation.familyUS 2003143657 (A1) 2003-07-31en_HK
patents.relation.familyUS 6733963 (B2) 2004-05-11en_HK
patents.relation.familyUS 2003148412 (A1) 2003-08-07en_HK
patents.relation.familyUS 6740498 (B2) 2004-05-25en_HK
patents.relation.familyUS 2003108979 (A1) 2003-06-12en_HK
patents.relation.familyUS 6806060 (B2) 2004-10-19en_HK
patents.relation.familyUS 2003186837 (A1) 2003-10-02en_HK
patents.relation.familyUS 6852484 (B2) 2005-02-08en_HK
patents.relation.familyWO 03050310 (A2) 2003-06-19en_HK
patents.description.kindA2en_HK
patents.typePatent_publisheden_HK

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