Granted Patent: Methods For The Identification Of Inhibitors Of 3-Isopropylmalate Dehydratase As Antibiotics

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TitleMethods For The Identification Of Inhibitors Of 3-Isopropylmalate Dehydratase As Antibiotics
Granted PatentUS 6733963
Granted Date2004-05-11
Priority Date2001-12-06 US 09/010227
InventorsHamer, L
Adachi, K
DeZwaan, T
Lo, CSC
Montenegro-Chamorro, MV
Frank, S
Darveaux, B
Mahanty, S
Heiniger, R
Skalchunes, A
Pan, H
Tarpey, R
Shuster, J
Tanzer, T
Tanzer, MM
CitationUS Patent 6733963. Washington, DC: US Patent and Trademark Office (USPTO), 2004 [How to Cite?]
AbstractThe Present Inventors Have Discovered That 3-Isopropylmalate Dehydratase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of 3-Isopropylmalate Dehydratase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, 3-Isopropylmalate Dehydratase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit 3-Isopropylmalate Dehydratase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.
ReferencesUS 5998420 (A) 1999-12-07

US 4920109 (A) 1990-04-24

US 4920111 (A) 1990-04-24

US 4920112 (A) 1990-04-24

US 4920113 (A) 1990-04-24

US 4921844 (A) 1990-05-01

US 5976848 (A) 1999-11-02

US 6074830 (A) 2000-06-13
DC Field
Value
dc.contributor.inventorHamer, L
dc.contributor.inventorAdachi, K
dc.contributor.inventorDeZwaan, T
dc.contributor.inventorLo, CSC
dc.contributor.inventorMontenegro-Chamorro, MV
dc.contributor.inventorFrank, S
dc.contributor.inventorDarveaux, B
dc.contributor.inventorMahanty, S
dc.contributor.inventorHeiniger, R
dc.contributor.inventorSkalchunes, A
dc.contributor.inventorPan, H
dc.contributor.inventorTarpey, R
dc.contributor.inventorShuster, J
dc.contributor.inventorTanzer, T
dc.contributor.inventorTanzer, MM
dc.date.accessioned2007-10-30T06:32:37Z
patents.date.application2001-12-06
dc.date.available2007-10-30T06:32:37Z
patents.date.granted2004-05-11
patents.date.priority2001-12-06 US 09/010227
patents.date.publication2003-07-31
dc.description.abstractThe Present Inventors Have Discovered That 3-Isopropylmalate Dehydratase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of 3-Isopropylmalate Dehydratase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, 3-Isopropylmalate Dehydratase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit 3-Isopropylmalate Dehydratase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.
patents.description.assigneeParadigm Genetics Inc [Us]
patents.description.ccUS
patents.description.countryUnited States of America
patents.description.kindB2
dc.description.naturepublished_or_final_version
dc.format.extent2864719 bytes
dc.format.extent2788 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
patents.identifier.applicationUS 09/010227
dc.identifier.citationUS Patent 6733963. Washington, DC: US Patent and Trademark Office (USPTO), 2004 [How to Cite?]
patents.identifier.grantedUS 6733963
patents.identifier.publicationUS 20030143657
dc.identifier.urihttp://hdl.handle.net/10722/45685
dc.languageeng
patents.relation.familyAU 2002363978 (A1) 2003-06-23
patents.relation.familyCA 2469695 (A1) 2003-06-19
patents.relation.familyEP 1461460 (A2) 2004-09-29
patents.relation.familyJP 2005524390 (A) 2005-08-18
patents.relation.familyUS 2003124642 (A1) 2003-07-03
patents.relation.familyUS 6689578 (B2) 2004-02-10
patents.relation.familyUS 2003143657 (A1) 2003-07-31
patents.relation.familyUS 6733963 (B2) 2004-05-11
patents.relation.familyUS 2003148412 (A1) 2003-08-07
patents.relation.familyUS 6740498 (B2) 2004-05-25
patents.relation.familyUS 2003108979 (A1) 2003-06-12
patents.relation.familyUS 6806060 (B2) 2004-10-19
patents.relation.familyUS 2003186837 (A1) 2003-10-02
patents.relation.familyUS 6852484 (B2) 2005-02-08
patents.relation.familyWO 03050310 (A2) 2003-06-19
dc.relation.referencesUS 5998420 (A) 1999-12-07
dc.relation.referencesUS 4920109 (A) 1990-04-24
dc.relation.referencesUS 4920111 (A) 1990-04-24
dc.relation.referencesUS 4920112 (A) 1990-04-24
dc.relation.referencesUS 4920113 (A) 1990-04-24
dc.relation.referencesUS 4921844 (A) 1990-05-01
dc.relation.referencesUS 5976848 (A) 1999-11-02
dc.relation.referencesUS 6074830 (A) 2000-06-13
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
dc.titleMethods For The Identification Of Inhibitors Of 3-Isopropylmalate Dehydratase As Antibiotics
dc.typePatent
patents.typePatent_granted