granted patent: Methods for the identification of inhibitors of histidinol-phosphate as antibiotics

TitleMethods for the identification of inhibitors of histidinol-phosphate as antibiotics
Granted PatentUS 6740498
Granted Date2004-05-25
Priority Date2001-12-06 US 09/010084
Inventors
Issue Date2004
Citation
US Patent US 6740498. Washington, DC: US Patent and Trademark Office (USPTO), 2004 How to Cite?
AbstractThe present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Persistent Identifierhttp://hdl.handle.net/10722/177034
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:58Z-
dc.date.available2012-11-30T08:38:58Z-
dc.date.issued2004-
dc.identifier.citationUS Patent US 6740498. Washington, DC: US Patent and Trademark Office (USPTO), 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177034-
dc.description.abstractThe present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMethods for the identification of inhibitors of histidinol-phosphate as antibioticsen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorAdachi Kiichien_HK
dc.contributor.inventorDezwaan Todden_HK
dc.contributor.inventorLo, CSCen_HK
dc.contributor.inventorFrank Sherylen_HK
dc.contributor.inventorDarveaux Blaiseen_HK
dc.contributor.inventorMahanty Sanjoyen_HK
dc.contributor.inventorHeiniger Ryanen_HK
dc.contributor.inventorSkalchunes Amyen_HK
dc.contributor.inventorPan Huaqinen_HK
dc.contributor.inventorTarpey Rexen_HK
dc.contributor.inventorShuster Jeffreyen_HK
dc.contributor.inventorTanzer Matthew Men_HK
dc.contributor.inventorHamer Lisbethen_HK
patents.identifier.applicationUS 09/010084en_HK
patents.identifier.grantedUS 6740498en_HK
patents.description.assigneePARADIGM GENETICS INC [US]en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.granted2004-05-25en_HK
dc.relation.referencesUS 4920109 (A) 1990-04-24en_HK
dc.relation.referencesUS 4920111 (A) 1990-04-24en_HK
dc.relation.referencesUS 4920112 (A) 1990-04-24en_HK
dc.relation.referencesUS 4920113 (A) 1990-04-24en_HK
dc.relation.referencesUS 4921844 (A) 1990-05-01en_HK
dc.relation.referencesUS 5976848 (A) 1999-11-02en_HK
dc.relation.referencesUS 6074830 (A) 2000-06-13en_HK
patents.date.application2001-12-06en_HK
patents.date.priority2001-12-06 US 09/010084en_HK
patents.description.ccUSen_HK
patents.relation.familyAU 2002363978 (A1) 2003-06-23en_HK
patents.relation.familyCA 2469695 (A1) 2003-06-19en_HK
patents.relation.familyEP 1461460 (A2) 2004-09-29en_HK
patents.relation.familyJP 2005524390 (A) 2005-08-18en_HK
patents.relation.familyUS 2003124642 (A1) 2003-07-03en_HK
patents.relation.familyUS 6689578 (B2) 2004-02-10en_HK
patents.relation.familyUS 2003143657 (A1) 2003-07-31en_HK
patents.relation.familyUS 6733963 (B2) 2004-05-11en_HK
patents.relation.familyUS 2003148412 (A1) 2003-08-07en_HK
patents.relation.familyUS 6740498 (B2) 2004-05-25en_HK
patents.relation.familyUS 2003108979 (A1) 2003-06-12en_HK
patents.relation.familyUS 6806060 (B2) 2004-10-19en_HK
patents.relation.familyUS 2003186837 (A1) 2003-10-02en_HK
patents.relation.familyUS 6852484 (B2) 2005-02-08en_HK
patents.relation.familyWO 03050310 (A2) 2003-06-19en_HK
patents.description.kindB2en_HK
patents.typePatent_granteden_HK

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