Granted Patent: Methods For The Identification Of Inhibitors Of Homocitrate Synthase As Antibiotics
| Title | Methods For The Identification Of Inhibitors Of Homocitrate Synthase As Antibiotics |
|---|---|
| Granted Patent | US 6632631 |
| Granted Date | 2003-10-14 |
| Priority Date | 2001-11-09 US 09/011200 |
| Inventors | Shuster, J Tanzer, T Hamer, L Adachi, K DeZwaan, T Lo, CSC Montenegro-Chamorro, MV Frank, S Darveaux, B Mahanty, S Heiniger, R Skalchunes, A Pan, H Tarpey, R |
| Citation | US Patent 6632631. Washington, DC: US Patent and Trademark Office (USPTO), 2003 [How to Cite?] |
| Abstract | The Present Inventors Have Discovered That Homocitrate Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Homocitrate Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Homocitrate Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit Homocitrate Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.</Ptext> |
| References | US 4920109 (A) 1990-04-24 US 4920111 (A) 1990-04-24 US 4920112 (A) 1990-04-24 US 4920113 (A) 1990-04-24 US 4921844 (A) 1990-05-01 US 5976848 (A) 1999-11-02 US 6074830 (A) 2000-06-13 |
| dc.contributor.inventor | Shuster, J |
|---|---|
| dc.contributor.inventor | Tanzer, T |
| dc.contributor.inventor | Hamer, L |
| dc.contributor.inventor | Adachi, K |
| dc.contributor.inventor | DeZwaan, T |
| dc.contributor.inventor | Lo, CSC |
| dc.contributor.inventor | Montenegro-Chamorro, MV |
| dc.contributor.inventor | Frank, S |
| dc.contributor.inventor | Darveaux, B |
| dc.contributor.inventor | Mahanty, S |
| dc.contributor.inventor | Heiniger, R |
| dc.contributor.inventor | Skalchunes, A |
| dc.contributor.inventor | Pan, H |
| dc.contributor.inventor | Tarpey, R |
| dc.date.accessioned | 2007-10-30T06:32:42Z |
| patents.date.application | 2001-11-09 |
| dc.date.available | 2007-10-30T06:32:42Z |
| patents.date.granted | 2003-10-14 |
| patents.date.priority | 2001-11-09 US 09/011200 |
| patents.date.publication | 2003-09-25 |
| dc.description.abstract | The Present Inventors Have Discovered That Homocitrate Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Homocitrate Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Homocitrate Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit Homocitrate Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.</Ptext> |
| patents.description.assignee | Paradigm Genetics Inc [Us] |
| patents.description.cc | US |
| patents.description.country | United States of America |
| patents.description.kind | B1 |
| dc.description.nature | published_or_final_version |
| dc.format.extent | 3078397 bytes |
| dc.format.extent | 2788 bytes |
| dc.format.mimetype | application/pdf |
| dc.format.mimetype | text/plain |
| patents.identifier.application | US 09/011200 |
| dc.identifier.citation | US Patent 6632631. Washington, DC: US Patent and Trademark Office (USPTO), 2003 [How to Cite?] |
| patents.identifier.granted | US 6632631 |
| patents.identifier.publication | US 20030180829 |
| dc.identifier.uri | http://hdl.handle.net/10722/45688 |
| dc.language | eng |
| patents.relation.family | AU 2002365038 (A8) 2003-06-10 |
| patents.relation.family | CA 2469772 (A1) 2003-06-05 |
| patents.relation.family | EP 1481080 (A2) 2004-12-01 |
| patents.relation.family | JP 2005510230 (A) 2005-04-21 |
| patents.relation.family | US 2003180829 (A1) 2003-09-25 |
| patents.relation.family | US 6632631 (B1) 2003-10-14 |
| patents.relation.family | US 2003104511 (A1) 2003-06-05 |
| patents.relation.family | US 6723529 (B2) 2004-04-20 |
| patents.relation.family | WO 03046130 (A2) 2003-06-05 |
| dc.relation.references | US 4920109 (A) 1990-04-24 |
| dc.relation.references | US 4920111 (A) 1990-04-24 |
| dc.relation.references | US 4920112 (A) 1990-04-24 |
| dc.relation.references | US 4920113 (A) 1990-04-24 |
| dc.relation.references | US 4921844 (A) 1990-05-01 |
| dc.relation.references | US 5976848 (A) 1999-11-02 |
| dc.relation.references | US 6074830 (A) 2000-06-13 |
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents |
| dc.title | Methods For The Identification Of Inhibitors Of Homocitrate Synthase As Antibiotics |
| dc.type | Patent |
| patents.type | Patent_granted |