published patent: METHODS FOR THE IDENTIFICATION OF INHIBITORS OF HOMOCITRATE SYNTHASE AS ANTIBIOTICS

TitleMETHODS FOR THE IDENTIFICATION OF INHIBITORS OF HOMOCITRATE SYNTHASE AS ANTIBIOTICS
Priority Date2001-11-09 US 09/011200
Inventors
Issue Date2003
Citation
US Published patent application US 2003180829. Washington, DC: US Patent and Trademark Office (USPTO), 2003 How to Cite?
AbstractThe present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Persistent Identifierhttp://hdl.handle.net/10722/176847

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:35Z-
dc.date.available2012-11-30T08:38:35Z-
dc.date.issued2003-
dc.identifier.citationUS Published patent application US 2003180829. Washington, DC: US Patent and Trademark Office (USPTO), 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176847-
dc.description.abstractThe present inventors have discovered that homocitrate synthase is essential for fungal pathogenicity. Specifically, the inhibition of homocitrate synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, homocitrate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit homocitrate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR THE IDENTIFICATION OF INHIBITORS OF HOMOCITRATE SYNTHASE AS ANTIBIOTICSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorShuster Jeffreyen_HK
dc.contributor.inventorTanzer Matthew Men_HK
dc.contributor.inventorHamer Lisbethen_HK
dc.contributor.inventorAdachi Kiichien_HK
dc.contributor.inventorDezwaan Todd Men_HK
dc.contributor.inventorLo, CSCen_HK
dc.contributor.inventorDarveaux Blaiseen_HK
dc.contributor.inventorFrank Sherylen_HK
dc.contributor.inventorHeiniger Ryanen_HK
dc.contributor.inventorMahanty Sanjoy Ken_HK
dc.contributor.inventorPan Huaqinen_HK
dc.contributor.inventorSkalchunes Amyen_HK
dc.contributor.inventorTarpey Rex Wen_HK
patents.identifier.applicationUS 09/011200en_HK
patents.description.assigneeSHUSTER JEFFREY, ; TANZER MATTHEW M, ; HAMER LISBETH, ; ADACHI KIICHI, ; DEZWAAN TODD M, ; LO SZE-CHUNG, ; MONTENEGRO-CHAMORRO MARIA VICTORIA, ; DARVEAUX BLAISE, ; FRANK SHERYL, ; HEINIGER RYAN, ; MAHANTY SANJOY K, ; PAN HUAQIN, ; SKALCHUNES AMY, ; TARPEY REX W, ; PARADIGM GENETICS, INCen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2003-09-25en_HK
patents.date.application2001-11-09en_HK
patents.date.priority2001-11-09 US 09/011200en_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2003180829en_HK
patents.relation.familyAU 2002365038 (A1) 2003-06-10en_HK
patents.relation.familyCA 2469772 (A1) 2003-06-05en_HK
patents.relation.familyEP 1481080 (A2) 2004-12-01en_HK
patents.relation.familyJP 2005510230 (A) 2005-04-21en_HK
patents.relation.familyUS 2003180829 (A1) 2003-09-25en_HK
patents.relation.familyUS 6632631 (B1) 2003-10-14en_HK
patents.relation.familyUS 2003104511 (A1) 2003-06-05en_HK
patents.relation.familyUS 6723529 (B2) 2004-04-20en_HK
patents.relation.familyWO 03046130 (A2) 2003-06-05en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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