published patent: METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ALPHA-AMINOADIPATE REDUCTASE AND HOMOCITRATE SYNTHASE AS ANTIBIOTICS

TitleMETHODS FOR THE IDENTIFICATION OF INHIBITORS OF ALPHA-AMINOADIPATE REDUCTASE AND HOMOCITRATE SYNTHASE AS ANTIBIOTICS
Priority Date2002-11-12 PCT/US2002036508
2001-11-09 US 09/011146
2001-11-09 US 09/011200
Inventors
Issue Date2004
Citation
EP Published Patent application EP 1481080. European Patent Office (EPO), Escapenet, 2004 How to Cite?
AbstractThe present inventors have discovered that alpha-Aminoadipate Reductase and Homocitrate Synthase are each essential for fungal pathogenicity. Specifically, the inhibition of alpha-Aminoadipate Reductase or Homocitrate Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, alpha-Aminoadipate Reductase or Homocitrate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit alpha-Aminoadipate Reductase or Homocitrate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.; The present inventors have discovered that [alpha]-Aminoadipate Reductase and Homocitrate Synthase are each essential for fungal pathogenicity. Specifically, the inhibition of [alpha]-Aminoadipate Reductase or Homocitrate Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, [alpha]-Aminoadipate Reductase or Homocitrate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit [alpha]-Aminoadipate Reductase or Homocitrate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Persistent Identifierhttp://hdl.handle.net/10722/176735

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:25Z-
dc.date.available2012-11-30T08:38:25Z-
dc.date.issued2004-
dc.identifier.citationEP Published Patent application EP 1481080. European Patent Office (EPO), Escapenet, 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176735-
dc.description.abstractThe present inventors have discovered that alpha-Aminoadipate Reductase and Homocitrate Synthase are each essential for fungal pathogenicity. Specifically, the inhibition of alpha-Aminoadipate Reductase or Homocitrate Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, alpha-Aminoadipate Reductase or Homocitrate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit alpha-Aminoadipate Reductase or Homocitrate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.; The present inventors have discovered that [alpha]-Aminoadipate Reductase and Homocitrate Synthase are each essential for fungal pathogenicity. Specifically, the inhibition of [alpha]-Aminoadipate Reductase or Homocitrate Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, [alpha]-Aminoadipate Reductase or Homocitrate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit [alpha]-Aminoadipate Reductase or Homocitrate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR THE IDENTIFICATION OF INHIBITORS OF ALPHA-AMINOADIPATE REDUCTASE AND HOMOCITRATE SYNTHASE AS ANTIBIOTICSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorTanzer, Matthewen_HK
dc.contributor.inventorShuster, Jeffreyen_HK
dc.contributor.inventorHamer, Lisbethen_HK
dc.contributor.inventorAdachi, Kiichien_HK
dc.contributor.inventorDezwaan, Todden_HK
dc.contributor.inventorLo, CSCen_HK
dc.contributor.inventorFrank, Sherylen_HK
dc.contributor.inventorDarveaux, Blaiseen_HK
dc.contributor.inventorMahanty, Sanjoyen_HK
dc.contributor.inventorHeiniger, Ryanen_HK
dc.contributor.inventorSkalchunes, Amyen_HK
dc.contributor.inventorPan, Huaquinen_HK
dc.contributor.inventorTarpey, Rexen_HK
patents.identifier.applicationEP 20020803979en_HK
patents.description.assigneePARADIGM GENETICS INC [US]en_HK
patents.description.countryEuropean Patent Officeen_HK
patents.date.publication2004-12-01en_HK
patents.date.application2002-11-12en_HK
patents.date.priority2002-11-12 PCT/US2002036508en_HK
patents.date.priority2001-11-09 US 09/011146en_HK
patents.date.priority2001-11-09 US 09/011200en_HK
patents.description.ccEPen_HK
patents.identifier.publicationEP 1481080en_HK
patents.relation.familyAU 2002365038 (A1) 2003-06-10en_HK
patents.relation.familyCA 2469772 (A1) 2003-06-05en_HK
patents.relation.familyEP 1481080 (A2) 2004-12-01en_HK
patents.relation.familyJP 2005510230 (A) 2005-04-21en_HK
patents.relation.familyUS 2003180829 (A1) 2003-09-25en_HK
patents.relation.familyUS 6632631 (B1) 2003-10-14en_HK
patents.relation.familyUS 2003104511 (A1) 2003-06-05en_HK
patents.relation.familyUS 6723529 (B2) 2004-04-20en_HK
patents.relation.familyWO 03046130 (A2) 2003-06-05en_HK
patents.description.kindA2en_HK
patents.typePatent_publisheden_HK

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