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Dr Chan, Koon Ho 陳灌豪

Title:
Clinical Associate Professor

Biography

K H Chan received his training in internal medicine and neurology in the University Department of Medicine, Faculty of Medicine, the University of Hong Kong. He obtained his fellowship in neurology in 2001 and joined the University of Hong Kong as Clinical Assistant Professor in 2008, and became Clinical Associate Professor in 2013. His recurrent focus on immune-mediated neurological disorders and related neuroimmunology. Multiple sclerosis (MS) is an important inflammatory demyelinating disorder of the central nervous system (CNS) with uncertain pathogenesis. Neuromyelitis optica (NMO) cause severe optic neuritis and acute myelitis, and not uncommonly misdiagnosed as MS. Detection of aquaporin-4 autoantibodies (AQP4 Ab) in serum of NMO patients greatly facilitate the diagnosis of NMO and its differentiation from MS. APQ4 is the most abundant water channel protein in mammalian CNS. NMO is more common among Asians with long-term treatments different from that of MS. Dr. Chan’s research focuses on 1) clinical and radiological features of local MS and NMO patients, 2) development of better assays to detect AQP4 Ab, 3) understanding immunopathogenesis of MS and NMO especially the pathogenic role of AQP4 Ab, 4) development of an ideal animal model of NMO, and 5) development of novel immunomodulatory therapies for MS and NMO. He is particularly interested in the role of regulatory B cells in MS and NMO. He  participates in international multi-center trial on new disease modifying therapies for MS and NMO. Among the line of neuroinflammation, he is actively researching on the pathogenetic mechanisms of Alzheimer’s disease (AD) focusing on neuroinflammation triggered by beta-amyloid (Aβ) in AD and potential neuroprotective action of adiponectin (an adipokine with anti-inflammatory effects) for AD.

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
2004-12-01Hong Kong West Cluster Healthy Staff Award For Nil Sick Leave For 10 Years From July 1994 To June 2004
Others
2004-09-01Hospital Authority Long Year Service Award
Others
2002-01-01Young Investigator's Award for Best Oral Presentation, 7th Medical Research Conference, Faculty of Medicine, The University of Hong Kong
Research Achievement
Ho, WM
Liu, H
So, HF
Tse, HM
Kung, MHW
Ramsden, DB
2011-04-01International Scholarship Award (AAN) 2011: American Academy of Neurology’s 2011
Research Achievement
Ho, WM
Liu, H
Yiu, CW
Kung, MHW
Ramsden, DB
2010-03-01"Emerging role of mitochondrial uncoupling protein-4 in neuronal differentiation and survival" - Young Investigator Award for the Oral Category: Fifth International Symposium on Healthy Aging: Is Aging a Disease? The Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 6-7 March 2010.
Research Achievement
2011-11-01Faculty Teaching Medal 2011: LKS Faculty of Medicine, The University of Hong Kong
Teaching Accomplishment
2012-07-01GRF Incentive Award: Univeristy Research Committee
Research Achievement
2000-01-01Poon Hung Chiu Scholarship For Elective Study In Neuroimmunology Research In Mayo Clinic, Rochester, USA
Research Achievement
2006-04-01Top 50 Abstracts Selected For Highlights In The 58th Annual Meeting Of The Amercial Academy Of Neurology
Research Achievement
Teo, KC
Lee, R
Chang, SK
2014-03-01Best Free Paper Award (First Runner-up): Antiplatelet Drugs Resumption after Antiplatelet-related Intra-cerebral Haemorrhage: 14th Asian & Oceanian Congress of Neurology
Research Achievement
Tse, CT
Tse, MMY
Pang, SYY
Ho, WM
2010-01-01Best Abstract In Clinical Medicine: 15th Medical Research Conference, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong
Research Achievement
2011-07-01Publication Award: Staff Research Incentive Scheme, Department of Medicine, The University of Hong Kong
Research Achievement
Chang, SKR
Doherty, I
Hon, SFK
Lee, R
Mak, W
2014-10-01ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU: HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia
Teaching Accomplishment
Ng, CL
Cheng, OY
Kwan, SC
2015-02-01Research Travel Scholarship 2015: American Academy of Neruology
Research Achievement
2014-12-01Twenty-Year Service Award: Hong Kong University-Hospital Authority Hong Kong West Cluster
Others
2016-08-01GRF Incentive Award: Department of Medicine, LKS Faculty of Medicine, HKU
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
07/2013-06/2015MemberNeurology Specialty Board, Hong Kong College of Physicians
since 01/2004Founding FellowHong Kong Stroke Society
since 03/2004MemberIntravenous Immunoglobulin Use in Neurological Diseases Asia Pacific Advisory Board
since 05/2012-12/2014ChairmanThe Hong Kong Multiple Sclerosis Society
since 01/1999Life MemberThe Hong Kong Neurological Society
01/2008 - 1/2009Council MemberThe Hong Kong Neurological Society
since 04/2001FellowHong Kong College of Medicine
since 01/2001Associate FellowAmerican Academy of Neurology
since 04/2009MemberAsia Pacific Experts Group in Myasthenia Gravis
since 08/2009FellowRoyal College of Physicians and Surgeons of Glasgow
07/2013-06/2015Regional Programme DirectorNeurology Specialty Board
since 04/2002FellowHong Kong Academy of Medicine
07/2015-06/2017Regional Programme DirectorNeurology Specialty Board, Hong Kong College of Physicians
since 01/2015Council MemberThe Hong Kong Multiple Sclerosis Society
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