Lam, KSL

Email Alert RSS Feed

 

Name Card
rp00343 picture

Professor Lam, Karen Siu Ling 林小玲

Title:
Rosie T T Young Professor in Endocrinology and Metabolism
Head, Department of Medicine
Professor: Chair of Medicine
Professor (Clinical)
Chairman, Clinical Trial Centre

Contact Information
rp00343 picture
Tel:
2255 4783
Office:

Professor Lam, Karen Siu Ling 林小玲

Title:
Rosie T T Young Professor in Endocrinology and Metabolism
Head, Department of Medicine
Professor: Chair of Medicine
Professor (Clinical)
Chairman, Clinical Trial Centre

Also Cited As:
Lam, Siu-ling, Karen
Lam, Karen
Lam, K

Professional Qualifications
YearAwarding InstitutionQualification
1976University of Hong KongM.B.B.S. (Hon.) H.K
1980Royal College of PhysiciansM.R.C.P. (U.K.)
1987Hong Kong Academy of MedicineF.H.K.C.P.
1990Royal College of Physicians of EdinburghF.R.C.P. (Edinburgh)
1990University of Hong KongM.D. (H.K.)
1993Hong Kong Academy of MedicineF.H.K.A.M. (Med)
1995Royal Australasian College of PhysiciansF.R.A.C.P.
1994Royal College of PhysiciansF.R.C.P. (London)
Biography

Professor Karen Lam is Chair Professor and Head of Medicine, Director of the Research Centre of Heart, Brain, Hormone & Healthy Aging, Chairman of Clinical Trial Centre and Clinical Director of the State Key Laboratory of Pharmaceutical Biotechnology (focusing on diabetes and obesity), at the University of Hong Kong. The Founding President of Diabetes Hongkong, she was also a president of the HK Endocrine Society and Chairman of two specialty boards of the HK College of Physicians – Advanced Internal Medicine and Endocrinology, Diabetes & Metabolism.

Research Profile

Professor Lam has published extensively on clinical, basic and translational research in diabetes and endocrinology, including publications in Diabetes, Diabetes Care, JCEM, ATVB, Circulation, Cell Metabolism, PNAS, JCI and Lancet. Heading an integrated research team with strengths and platforms ranging from cell and animal based research to epidemiological, genetic and clinic-based studies, her current research focuses on the pathogenetic and therapeutic significance of adipokines in diabetes and other obesity-related cardiometabolic disorders. She leads the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS; 1995-2014), a population-based cohort study on cardiovascular (CV) risk factors and diseases with the longest follow-up in China, which serves to chart the rise in obesity and metabolic syndrome in Southern China, as well as providing the database and biobank for investigating the interaction of environmental and genetic factors underlying obesity, diabetes and CV diseases in Chinese. The above platforms, database and biobanks have allowed her team to identity novel biomarkers of cardiometabolic diseases and demonstrate their clinical significance, notable examples being the adipocyte fatty acid binding protein (A-FABP) and fibroblast growth factor 21 (FGF21), which have inspired numerous follow-up studies in the field, from the international community.

Her team was the first to demonstrate that serum levels of A-FABP, a proinflammatory adipokine associated with insulin resistance, are raised in obesity and predict the development of the metabolic syndrome and type 2 diabetes (T2DM) (Clin Chem 2006; Circulation 2007; Diabetes Care 2007). She and her collaborators have subsequently confirmed its clinical significance in diabetic nephropathy (Diabetes Care 2009), stroke (Neurology 2011) and other CV diseases (ATVB 2007; EHJ 2008; JAHA 2013), fatty liver diseases (Hepatology 2009), and obstructive sleep apnoea (ERJ 2009); elucidated its regulation by the C-Jun NH2-terminal kinase (JNK) inflammatory signaling (JBC 2010; Diabetes 2011), and demonstrated the effectiveness of a small molecule A-FABP inhibitor in treating fatty liver diseases (J Hepatol 2013). In addition, her study on a transgenic mouse with adipose tissue specific JNK inactivation (Diabetes 2011) highlighted the importance of JNK activation in linking adipose tissue inflammation, dysregulated adipokine secretion and insulin resistance in obesity. For FGF21, a hormone previously considered as largely a hepatokine, her paper in Diabetes 2008 provided the first evidence that the FGF21 expression in the adipocytes is markedly increased in obesity, leading to raised circulating FGF21 levels. She subsequently showed that high FGF21 levels could predict the development of T2DM (Diabetes Care 2011) and distinguish T2DM from autoimmune diabetes (JCEM 2012). As beneficial metabolic effects of FGF21 and its analog are observed in animals and humans, respectively, this paradoxical increase in FGF21 levels suggests that obesity is associated with FGF21 resistance. Her findings have been confirmed by numerous other groups. Subsequent studies conducted by her group and others have also reported elevated FGF21 levels in atherosclerosis (ATVB 2013), fatty liver and other obesity related disorders. The underlying mechanisms of FGF21 resistance, which will impact on the therapeutic use of FGF21, have elucidated by her group (Diabetes 2013) and other researchers.  Her work on the genetics of obesity and diabetes, including the first demonstration that obesity susceptibility gene variants identified from GWAS in Caucasians are also clinically relevant to Chinese (JCEM 2010; EJE 2011), has led to invitations of international collaborations (Diabetologia 2012; Diabetes 2013).

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Li, FYL
2010-03-01Outstanding Abstract Prize, Fifth International Symposium On Healthy Aging: Is Aging A Disease?: Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong
Research Achievement
2013-04-01Integrated Diabetes Care Centre: Hong Kong West & Queen Mary Hospital Outstanding Team Award
Others
2007-08-01Excellent Research Award, Health Services Research Fund: HKSAR Food & Health Burea
Research Achievement
Chiu, SSH
Pang, CBY
2007-10-27Variability of coronary artery calcium scoring using 64-slice MDCT: Best Poster Award at 2nd Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 15th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 27-28 October 2007
Research Achievement
2006-01-01Best Oral Presentation Award: 11th Medical Research Conference 2006
Research Achievement
LEE, PC
SHU, L
Zhou, M
2014-01-01Best Abstract in Basic Science and translational (Oral Presentation): 19th Medical Research Conference
Research Achievement
Li, FYL
Wang, Y
2012-02-01Best Abstract in Basic Science and Translational Medicine: 17th Medical Research Conference
Research Achievement
Liu, J
Chen, J
Shepherd, PR
2011-11-01Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation: The 18th Hong Kong International Cancer Conference
Research Achievement
LEE, PC
SHU, L
Zhou, M
2014-01-01Best Abstract in Basic Science and Translational (Oral Presentation): 19th Medical Research Conference
Research Achievement
2014-07-01Honorary President: Diabetes Hongkong
Others
LEE, PC
Zhou, M
2012-12-01Best Oral Presentation Award: 7th International HuaXia Congress of Endocrinology
Research Achievement
2005-06-01Rosie TT Young Endowed Professorship in Endocrinology & Metaolism: The University of Hong Kong
Teaching Accomplishment
2008-07-01Outstanding Women Professionals and Entrepreneurs Award 2008: Hong Kong Women Professionals & Entrepreneurs Association
Others
LEE, PC
SHU, L
Zhou, M
2013-01-01Best Oral Presnetation Award: Research Centre Of Heart, Brain, Hormone & Healthy Aging, University of Hong Kong
Research Achievement
Cheung, MKT
2013-08-21Diabetes Risk Score smartphone application (DRS app): its application in diabetes prevention and health education: Knowledge Exchange (KE) Fund Exercise 2013/14 – Impact Project, UGC
Research Achievement
Li, FYL
2010-08-01Outstanding Scientific Work – Winning poster presentation: Frontiers in Cardiovascular Biology; European Society of Cardiology
Research Achievement
Ng, CL
Cheng, OY
Kwan, SC
2015-02-01Research Travel Scholarship 2015: American Academy of Neruology
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
1989 - 1992Council MemberWestern Pacific Region, International Diabetes Federation
since 1995Member, Education and Accreditation CommitteeHong Kong College of Physicians
2001Chairman, Specialty Board in Advanced Internal MedicineHong Kong College of Physicians
1996-2001Vice-ChairmanHong Kong College of Physicians
1994-2001Chairman, Specialty Board in Endocrinology & MetabolismHong Kong College of Physicians
1995-2001Regional College Advisor, Hong Kong IslandHong Kong College of Physicians
since 1996Council MemberDiabetes Hong Kong
1996-2000PresidentDiabetes Hong Kong
since 1990Country RepresentativeAsia-Oceania Society of Endocrinology
since 1996MemberCentral Committee, International Society of Endocrinology
1992-1994PresidentHong Kong Society for the Study of Endocrinology, Metabolism and Reproduction
1990–1992Chairman of Diabetes DivisionHong Kong Society for the Study of Endocrinology, Metabolism and Reproduction
1988-1990Hon. SecretaryHong Kong Society for the Study of Endocrinology, Metabolism and Reproduction
1990-2002Council MemberHong Kong Society for the Study of Endocrinology, Metabolism and Reproduction
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!
Loading Content...Please Wait!