Dr Philip Ho 何永樂
Dr. Philip Wing-Lok Ho obtained his PhD degree in the Department of Medicine, the University of Hong Kong in 2004. Currently, Dr Ho works at the position of Research Assistant Professor in the Department of Medicine under division of neurology, HKU. Area of research includes: 1) Functional role of LRRK2 mutation in PD using in vitro & in vivo models: We have generated in-house a LRRK2 R1441G knockin mouse colony. Using this mouse colony we study the functional role of LRRK2 and its pathogenic mechanisms leading to PD. 2) Functions of mitochondrial uncoupling proteins (i.e. UCP2, 4 and 5) in neuronal system using both overexpression and knockdown of UCPs in neuronal cell models. Mechanisms of neuroprotection by UCPs against mitochondrial dysfunction in neurological disorders were determined by their effects on mitochondria bioenergetics including mitochondria morphology, activities of Complexes on mitochondrial electron transport chain, oxygen consumption, ATP synthesis, and oxidative stress. 3) Gene regulation of human neuronal UCP4 based on characterization of its gene promoter region, and identification of transcriptional regulatory elements (i.e. NF-kB). Our studies showed direct regulatory linkages of UCP4 to the pro-survival NF-kB pathways, and may be important in neuroinflammatory processes in Parkinson’s disease (PD). 4) Invention (design & synthesis) of a novel protein tag (patent pending), immunization and purification of antibodies against this protein tag for labeling and detection of target recombinant proteins. 5) Development of a novel COMT ELISA kit (patent pending) to detect estrogenic endocrine disruption for a compound or substance. Working principle of this novel ELISA assay is based on suppression of COMT expression in response to estrogen or its mimics (e.g. plasticizers). Development of this kit has significant impact on studying carcinogenic effects of xeno-estrogens in daily exposure to these environmental toxins, including phthalate-based plasticizers, and bis-phenol A.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2007-03-01||Leptin enhances MPP+-induced mitochondrial dysfunction: a potential for neuroprotection in Parkinsonism: Second International Symposium on Healthy Aging: Meeting the Challenges of an Aging Population, The Research Centre of Heart, Brain, Hormone and Healthy Aging, HKU - Outstanding Abstract Prize (Oral)||Research Achievement|
|2011-04-01||International Scholarship Award (AAN) 2011: American Academy of Neurology’s 2011||Research Achievement|
|2010-01-01||Best Abstract In Clinical Medicine: 15th Medical Research Conference, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong||Research Achievement|
|2010-03-01||"Emerging role of mitochondrial uncoupling protein-4 in neuronal differentiation and survival" - Young Investigator Award for the Oral Category: Fifth International Symposium on Healthy Aging: Is Aging a Disease? The Research Centre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong, 6-7 March 2010.||Research Achievement|
|2007-02-01||Leptin enhances MPP+-induced mitochondrial dysfunction: a potential for neuroprotection in Parkinsonism: Medical Research Conference, HKU - Best Presentation Award||Research Achievement|
|2015-02-01||Research Travel Scholarship 2015: American Academy of Neruology||Research Achievement|
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