Kwan, Joseph Shiu Kwong

 

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Dr Kwan, Joseph Shiu Kwong 關兆洸

Title:
Clinical Associate Professor
Honorary Consultant Geriatrician, Queen Mary Hospital
Director, HKU Gerontology Research Laboratory
Member, Bau Institute of Medical & Health Sciences Education
Visiting Professor, Bournemouth University, UK

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2255 4769
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Dr Kwan, Joseph Shiu Kwong 關兆洸

Title:
Clinical Associate Professor
Honorary Consultant Geriatrician, Queen Mary Hospital
Director, HKU Gerontology Research Laboratory
Member, Bau Institute of Medical & Health Sciences Education
Visiting Professor, Bournemouth University, UK

Also Cited As:
Kwan, J
Kwan, JS
Kwan, JSK
Kwan, Joseph

Short Biography:

Dr Joseph SK Kwan

MB ChB (Bristol) MRCP (UK) MPhil (Southampton) MD (Edinburgh) FRCP (Edinburgh) FRCP (London) FHKCP FHKAM (Medicine) FRSPH (UK)

Joseph graduated in Medicine from Bristol University (1994), Master of Philosophy from Southampton University (2000), and Doctor of Medicine from Edinburgh University (2002). He received his post-doctoral specialist training in General Internal Medicine and Geriatric Medicine in Southampton (Wessex), Clinical Neurology Fellowship at Queen Square London (Institute of Neurology, University College London), and Plant-Based Nutrition at Cornell University. He became a Fellow of the Royal College of Physicians (Edinburgh) in 2009, Royal College of Physicians (London) in 2010, and Royal Society of Public Health (UK) in 2017.

Joseph returned to join The University of Hong Kong in 2014 as a Clinical Associate Professor, and Honorary Consultant in Queen Mary Hospital. He became a Fellow of the HK College of Physicians and HK Academy of Medicine (Medicine) in 2016. As a Specialist in Geriatric Medicine, he has a particular interest in neurological conditions of aging including dementia, stroke, Parkinson's disease and neuro-rehabilitation.

Joseph's research focuses on the major non-communicable diseases of aging including Alzheimer's disease, heart & brain health, and frailty prevention through exercise & nutrition. He founded the Gerontology Research Laboratory at the LKS Faculty of Medicine, and is the Principal investigator for the HKU Neurocognitive Disorder Cohort (linked to the Dementias Platform UK), HKU Memory Clinic Registry, and the HKU Elderly AF Treatment Registry. Joseph is a collaborative researcher with networks of clinicians and basic scientists both locally and internationally.

For medical education, Joseph serves as a Member of the HKCP Specialty Board in Geriatric Medicine, the Chief Examiner for the MCHK Licentiate Examination (English paper), and a Co-Chairman for the Assessment Sub-Committee for the HKU LKS Faculty of Medicine. Through BIMHSE, he focuses on promoting: a) humanistic and compassionate caring attitudes for medical trainees; b) professionalism and ethical practice through the MEHU; c) critical thinking, free self-expression and open debate on difficult issues; and d) self-preservation of physical and psychological health of doctors.

Professional Qualifications
YearAwarding InstitutionQualification
1994The University of BristolMB ChB
1997Royal College of PhysiciansMRCP
2000The University of SouthamptonMaster of Philosophy (MPhil)
2002The University of EdinburghDoctor of Medicine (MD)
2006University College LondonPostgraduate Diploma in Clinical Neurology (distinction)
2009Royal College of Physicians of EdinburghFRCP (Edin)
2010Royal College of Physicians of LondonFRCP (London)
2015Cornell University (eCornell)Certificate in Plant-Based Nutrition
2016Hong Kong College of PhysiciansFHKCP
2016Hong Kong Academy of MedicineFHKAM (Medicine)
2017Royal Society for Public HealthFRSPH
Biography

ACADEMIC QUALIFICATIONS

  • 2017                   Fellowship of the Royal Society for Public Health (FRSPH)
  • 2016                   Fellowship of the Hong Kong Academy of Medicine (FHKAM [Medicine])
  • 2016                   Fellowship of the Hong Kong College of Physicians (FHKCP)
  • 2015                   Certificate in Plant-Based Nutrition (Cornell University, USA)
  • 2010                   Fellowship of the Royal College of Physicians of London (FRCP Lond)
  • 2009                   Fellowship of the Royal College of Physicians of Edinburgh (FRCP Edin)
  • 2006                   Postgraduate Diploma in Clinical Neurology with Distinction (UCL London, UK)
  • 2002                   Doctor of Medicine (MD, University of Edinburgh, UK)
  • 2000                   Master of Philosophy (MPhil, University of Southampton, UK)
  • 1997                   Membership of the Royal College of Physician (MRCP UK)
  • 1994                   MB ChB (University of Bristol, UK)

CLINICAL ACADEMIC POSITIONS

  • 2017-now           Member, Bau Institite of Medical & Health Sciences Education
  • 2017-now           Specality Board Member for Geriatric Medicine, HK College of Physicians
  • 2016                   Visiting Scholar, UCSF Memory and Aging Center, San Francisco, USA          
  • 2015-now           Director, Gerontology Research Laboratory, Department of Medicine, HKU
  • 2014-now           Clinical Associate Professor in Geriatric Medicine, Department of Medicine, HKU
  • 2014-2015          Clinical teacher, Neurological Diseases Unit, HKU-Shenzhen Hospital, Shenzhen, China
  • 2010-2012          Head of Department, Stroke Medicine, Royal Bournemouth Hospital, UK
  • 2009-2011          Regional Medical Director for Stroke Service, Dorset, UK
  • 2006-2013          Consultant Physician in Gerontology, Stroke & Internal Medicine, Royal Bournemouth Hospital, UK
  • 2006                   Neurology Fellow, Insitute of Neurology, Queen Square, UK
  • 2002-2006          Post-doctoral Clinical & Research Trainee in Internal & Geriatric Medicine (University of Southampton, UK)
  • 2001-2002          Stroke Association Clinical training/Research Fellow (MD, University of Edinbuirgh, UK)
  • 2000-2001          Glaxo Wellcome Stroke Clinical training/Research Fellow (MD, University of Edinbuirgh, UK)
  • 1998-2000          Research Fellow in Stroke Medicine (MPhil, University of Southampton, UK)

HONORARY POSITIONS

  • 2014-now           Honorary Research Fellow, Sau Po Centre on Ageing, The University of Hong Kong, HK
  • 2014-now           Honorary Clinical Associate Professor, Department of Family Medicine & Primary Care, HKU
  • 2014-now           Honorary Consultant Gerontologist, Department of Medicine, Queen Mary Hospital, HK
  • 2014-now           Honorary Consultant Gerontologist, Department of Medicine, Grantham Hospital, HK
  • 2008-now           Visiting Professor, Bournemouth University, UK
  • 2006-2013          Honorary Senior Clinical Lecturer, Southampton University, UK

RESEARCH FUNDING PORTFOLIO

  • 2017                    Google Scholar: h-index 26 i-10-index 35
  • 2017                    Liu Po Shan Endowment Fund for Motor Neuron Disease: new registry of FTD/MND cohort (PI)
  • 2017                    HK Jockey Club Charities Trust: Persoanlised, Holistic Integrative Rehab Care (Advisor, HKSR)
  • 2017                    Novartis Ltd. research donation - HKU Memory Clinic Registry (PI)
  • 2017                    Pfizer Ltd. research donation - MRI of heart and brain in patients with atrial fibrillation (PI)
  • 2017                    Seed Fund (HKU) - Zebrafish as a model to investigate the biological effects of exercise
  • 2016-now            QMH TRAS: Benefit to the older people who train and work as exercise coaches (PI)
  • 2016-now            Prenetics Ltd. research donation - Genetic determination of response to dementia drugs (PI)
  • 2016-now            Lee Hysan Foundation: Carer stress after stroke (Co-I)
  • 2016-now            SY Lee Foundation: GrandMove and GrandMove Plus Studies (Co-I)
  • 2016-now            HMRF: Advance care planning in older people (Co-A)
  • 2015-now            GRF: Neurobiology of cerebral aging (Co-I)
  • 2015-now            Seed Fund for Collaborative Research (HKU): Visual impairment in Alzheimer's disease (Co-PI)
  • 2015-now            Seed Fund for Collaborative Research (HKU): Cancer care in older people: geri-oncology (Co-PI)
  • 2015-now            Seed Fund for Collaborative Research (HKU): Cognitive reserve and neuroplasticity in aging (Co-PI)
  • 2015-now            Development Fund for Medical Humanities (HKU) - Humanism in Aging (PI)
  • 2014-now            Seed Fund (HKU) - Multimodal comparison study of vascular dementia vs Alzheimer's disease (PI)
  • 2014-now            Boehringer-Ingelheim Ltd. donation - MRI correlates of cerebrovascular disease and patient outcome (PI)
  • 2014-now            Start-up Fund (HKU) - Clinical correlates of cerebral microbleeds and white matter ischaemia on MRI (PI)

MEDICAL RESEARCH - ONGOING PROJECTS

1) Dementia

  • Formal linkage of HKU Neurocognitive Disorders Cohort to the Dementias Platform UK (PI)
  • HKU Neurocognitive Disorders Cohort – prospective study of patients with subjective cognitive decline & mild cognitive impairment (PI)
  • HKU Memory Clinic Registry – retrospective study of all HKU Memory Clinic patients since 2002 (PI, Novartis Ltd.)
  • Improving the quality of life for nursing home residents with dementia (PI, Advisor for Project PHI, HKJC Charitable Trust)
  • FTD/MND in Hong Kong (PI, Liu Po Shan Endowment Fund)
  • Neuroimaging study of cerebral ageing (Co-I, GRF)
  • High definition EEG (Event-Response Potential) as a biomarker for pathological subjective cognitive decline (PI, MPhil)
  • Amyloid PET (F18 Flutametamol) vs. MRI in Alzheimer's disease and vascular dementia (Co-I)
  • Micro-RNA biomarkers in dementia (Co-I)
  • Microvesicles as biomarkers of dementia (PI)
  • Genetic determination of response to cholinesterase inhibitors in patients with Alzheimer's Disease (PI, Prenetics Ltd.)
  • Genetic determination of response to antipsychotic medications in patients with dementia/behavioural and psychiatric symptoms (PI, Prenetics Ltd.)
  • Computerised assessment of brain function in aging and dementia – laptop and tablet-based tools (PI)
  • Bilingualism for cerebral protection in patients with mild cognitive impairment (PI)
  • Validation of the Oxford Cognitive Screen - Plus (OCS-P) tool (Co-I)
  • Association between depressive mood and memory decline in community dwelling adults (PI)
  • Expressive art therapy for dementia and delirium (Co-I)
  • Eye movement tracking as an early biomarker for dementia (Co-I)
  • Retinal thickness as an early biomarker for dementia (Co-I, CRF Seed)
  • Cognitive function and effective use of eye drops (Co-I)
  • Cognitive reserve and retirement (Co-I, CRF Seed)
  • Carer stress in dementia patients with dementia/behavioural and psychiatric symptoms (PI)
  • Evaluation study of dementia community support scheme (Co-I, Food and Health Bureau)
  • Comparisons of MMSE and HK-MOCA in an older Chinese population (Co-I)

2) Heart and brain

  • HKU Elderly AF Treatment Registry – prospective study of older patients with atrial fibrillation (PI, Boehringer-Ingelheim Ltd.)
  • Development of new-onset dementia in patients with atrial fibrillation (Co-I)
  • Prospective study of cognitive decline in older patients with atrial fibrillation (PI)
  • MRI of heart and brain in patients with atrial fibrillation (PI, Pfizer Ltd.)
  • Optimal treatment pathway of atrial fibrillation in older people (PI)
  • AF screening in the high risk elderly population (Co-I)

3) Stroke / small vessel disease

  • MRI makers of small vessel disease as predictors of cognitive decline in subjective cognitive decline & mild cognitive impairment (PI)
  • MRI makers of small vessel disease as predictors of outcome after stroke rehabilitation (PI)
  • MRI-derived structural connectivity as a predictor of outcome after stroke rehabilitation (Co-I)
  • Cochrane review of anti-thrombotic agents to prevent dementia in patients with small vessel disease on MRI (PI)
  • Cochrane review of anti-epileptic drugs to prevent seizures after stroke (PI)
  • Cochrane review of anti-epileptic drugs to prevent seizures after subarachnoid haemorrhage (PI)
  • Cochrane review of anti-epileptic drugs to prevent seizures after intracranial venous thrombosis (PI)
  • Transcranial Direct Current Stimulation (tDCS) for dysarthria after stroke (Co-I)
  • We-Rise Project on carer stress after stroke (Co-I, Lee Hysan Foundation)

4) Frailty and sarcopenia

  • Intensive rehabilitation to prevent and reverse frailty (PI, Advisor for Project PHI, HKJC Charitable Trust)
  • Frailty and sarcopenia in older people with AF (PI)
  • Frailty and sarcopenia in patients with SCD, MCI and dementia (PI)
  • Frailty in older community dwelling adults in Hong Kong (Co-I)
  • Frailty and its clinical consequence in Old Age Homes in Hong Kong (Co-I)
  • Study of Centenarians in Hong Kong (Co-I)
  • Tanner Hill Project of frailty prevention in older people (Co-I)
  • SEN Project of frailty prevention in older people (Co-I)
  • Impact of frailty on the selection and outcome of patients for cardiothoracic surgery (Co-I)
  • Impact of frailty on the selection and outcome of patients for breast cancer treatments (Co-I)
  • Hong Kong Society on Rehabilitation Project of intensive rehabilitation to treat physical and cognitive frailty (Co-I, Jockey Club)
  • Outcome study of older people with intellectual disability in Hong Kong (Co-I)
  • Contractures and their impact on old age home residents (PI, Inter-RAI)

5) Exercise

  • Zebrafish as a model to investigate the biological effects of exercise (PI, PhD)
  • Zebrafish as a model to evaluate autophagy in aging and exercise (PI, PhD)
  • GrandMove – randomised controlled trial of exercise intervention for community dwelling older people (Co-I, SY Lee Foundation)
  • GrandMove Plus – randomised controlled trial of exercise intervention for frail old age home residents (Co-I, SY Lee Foundation)
  • Benefit to the older people who train and work as exercise coaches (PI, QMH TRAS funding)

6) End of life and ethics

  • Advanced Care Planning education for the public (Co-I, HMRF)
  • End of life pathway in the acute hospital (Co-I)
  • Use of restraints and its impact in old age homes (PI, Inter-RAI)
 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
2011-07-01"Excellence in Practice National Team of the Year” Award: Arrhythmia Alliance, UK
Others
Chan, FHW
Yau, SZM
2015-01-01Humanism in Aging: Intergenerational and Experiential Learning in the Community ($100,000): Development Fund for Medical Humanities, LKS Faculty of Medicine (HKU)
Research Achievement
2002-07-01Integrated Care Pathways for Acute Stroke: Doctor of Medicine (MD) Thesis. University of Edinburgh
Research Achievement
2009-07-01“Innovative Health and Social Care Technology” Award: NHS South West of England, UK
Others
2001-01-01Stroke Association Clinical Training Fellowship (Edinburgh University): The Stroke Association, UK
Research Achievement
2014-03-01Study on the interaction between vascular risk factors, MRI, cognition and outcome ($300,000): Start-Up Grant, Department of Medicine, HKU
Research Achievement
2000-01-01Best oral presentation prize at BASP Annual Scientific Conference: British Association of Stroke Physicians, UK
Research Achievement
2000-07-01Recovery of cerebral autoregulation during the first three months after acute ischaemic stroke – a longitudinal study using transcranial Doppler ultrasonography: Master of Philosophy (MPhil) Thesis, University of Southampton
Research Achievement
2006-03-01Pat Harris Prize (Postgraduate Diploma in Clinical Neurology with Distinction, top student): University College London, UK
Others
2001-01-01Glaxo Wellcome Clinical Training Fellowship (Edinburgh University): Glaxo Wellcome
Research Achievement
Chu, LW
Chan, HWF
2014-07-01Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000): Seed Funding HKU
Research Achievement
2015-06-01Dr Ng Ngai-sing Prize For Outstanding Free Paper Presentation (Annual Scientific Meeting 2015): Hong Kong Geriatrics Society
Research Achievement
Chang, SKR
Doherty, I
Hon, SFK
Lee, R
Mak, W
2014-10-01ePoster Award (First Prize), Title: Establishing an eLearning Platform in Clinical Neurosciences at HKU: HKU Li Ka Shing Faculty of Medicine Frontiers Series – East-West Alliance Global Symposia
Teaching Accomplishment
2016-05-01HKU Overseas Fellowship Award 2016-7 (UCSF Memory & Aging Center Overseas Scholarship): HKU
Research Achievement
2015-06-01Outstanding Investigator Award (1st Runner Up): International Alzheimer’s Disease Conference 2015 (HKU)
Research Achievement
2016-07-01Research Donation: "Genetic determination of responses to dementia drugs in patients with Alzheimer's Disease, and to antipsychotic drugs in patients with BPSD": Prenetics Ltd.
Research Achievement
2016-12-01UCL Global Engagement Fund (Collaborator £1810): University College London
Others
Professional Societies
Term PeriodPositionProfessional Societies
06/2014-MemberAsian Working Group for Sarcopenia
01/2014-MemberHKU Alzheimer's Disease Research
01/2014-MemberAmerican Geriatrics Society
01/1998-MemberBritish Geriatrics Society
01/2014-InvestigatorHKU Heart, Brain, Hormone and Healthy Ageing Centre
01/2000-2013MemberBritish Association of Stroke Physicians
01/2006-2013MemberBritish Society for Research on Ageing
12/2015-MemberChinese Dementia Research Association
01/2006-2013MemberQueen Square Alumnus Association
01/2014-MemberHK Geriatrics Society
06/2017-MemberHKCP - Geriatric Medicine Specialty Board
06/2016-Chief Examiner for English ProficiencyHong Kong Medical Council
Major Research Themes & Current Projects
DescriptionTitle
Principle Investigator - prospective cohort of patients with dementia, mild cognitive impairment (MCI) and Subjective Cognitive Decline (SCD), internationally linked to NACC (USA) and Dementia Platforms UKHKU Neurocognitive Disorder Cohort
Principle InvestigatorHKU Elderly Atrial Fibrillation Treatment Registry
Principle InvestigatorHKU Memory Clinic Registry
Principle InvestigatorMRI and Stroke Rehabilitation Outcomes
Principle InvestigatorGenetic determination of response to cholinesterase inhibitors in patients with Alzheimer's Disease
Principle InvestigatorHigh definition EEG (Event-Response Potential) Biomarkers in Dementia
Principle InvestigatorGenetic Determinants of Response to Antipsychotic Medications in Patients with Dementia
Media Contact Directory
Area of Expertise:
Area of Expertise (EN)Area of Expertise (ZH)
Dementia
Stroke
Aging
Geriatric Medicine
Spoken Languages:
Spoken Language(s) (EN)Spoken Language(s) (ZH)
English
Cantonese
Written Languages:
Written Language(s) (EN)Written Language(s) (ZH)
English
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