Kwan, Joseph Shiu Kwong

 

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Dr Kwan, Joseph Shiu Kwong 關兆洸

Title:
Clinical Associate Professor
Honorary Consultant Geriatrician, Queen Mary Hospital
Director, HKU Gerontology Research Laboratory
Member, Bau Institute of Medical & Health Sciences Education
Visiting Professor, Bournemouth University, UK

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Tel:
2255 4769
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Dr Kwan, Joseph Shiu Kwong 關兆洸

Title:
Clinical Associate Professor
Honorary Consultant Geriatrician, Queen Mary Hospital
Director, HKU Gerontology Research Laboratory
Member, Bau Institute of Medical & Health Sciences Education
Visiting Professor, Bournemouth University, UK

Research Interests:(click to check for cognate researchers)

Also Cited As:
Kwan, J
Kwan, JS
Kwan, JSK
Kwan, Joseph

Short Biography:

Dr Joseph SK Kwan

MB ChB (Bristol) MRCP (UK) MPhil (Southampton) MD (Edinburgh) FRCP (Edinburgh) FRCP (London) FHKCP FHKAM (Medicine) FRSPH (UK)

Specialist in Geriatric Medicine

As a British-bred and qualified physian, Joseph received his specialist training in Internal Medicine and Geriatric Medicine in Wessex (UK), Clinical Neurology Fellowship at Queen Square London (Institute of Neurology, UCL), and Plant-Based Nutrition at Cornell University. In England, he worked as the Senior Stroke Specialist and Head of Department of Stroke Medicine at the Royal Bournemouth Hospital, and the Regional Medical Director for the Clinical Stroke Network in the Dorset County, UK. In 2014, Joseph joined HKU as a Clinical Associate Professor, and Honorary Consultant in Queen Mary Hospital. 

His research focuses on the major non-communicable diseases of aging:

1) Dementia & delirium. Joseph is the PI for the HKU Neurocognitive Disorder Cohort (linked to the Dementias Platform UK), HKU Memory Clinic Registry, and the convenor for the Hong Kong Delirium Working Group.: The aim is to study the early detection of cognitive decline (via validation of the Cantonese TabCAT to assess cognition using iPad) & delirium (via validation of the Cantonese 4AT), and the predictive biomarkers of future cognitive decline using MRI, PET scan and EEG. His team is also developing a new IT platform to deliver remote group cognitive stimulation therapy (CST) at home (FaceCog Project).

2) Heart & brain health. Joseph is the PI for the HKU Elderly AF Treatment Registry, which aims to examine the physical and cognitive impacts of AF in older patients, and the influence of different treatment strategies.

3) Frailty and exercise. Joseph is on the Strategic Planning Group for the HKJC-funed "Personalised, Holistic and Intensive rehabilitation to reduce the effects of frailty in older people" (PHI Project). He is also the PI for the evaluation of training older people as exercise coaches, and the introduction of new exercise regime in HK. He also founded the Gerontology Research Laboratory at the LKS Faculty of Medicine in 2015, and his lab is currently working on the molecular effects of excercise interventions on aging and cognition using novel zebrafish models.

4) Cancer-related cachexia and sarcopenia. He is currently planning clinical studies on CT assessment of muscle mass; prognostic impact of cancer-related weight loss, cachexia and sarcopenia; and the use of modified Glasgow Prognostic Score and frailty assessment for geriatric oncology patients.

Professional Qualifications
YearAwarding InstitutionQualification
1994The University of BristolMB ChB
1997Royal College of PhysiciansMRCP
2000The University of SouthamptonMaster of Philosophy (MPhil)
2002The University of EdinburghDoctor of Medicine (MD)
2006University College LondonPostgraduate Diploma in Clinical Neurology (distinction)
2009Royal College of Physicians of EdinburghFRCP (Edin)
2010Royal College of Physicians of LondonFRCP (London)
2015Cornell University (eCornell)Certificate in Plant-Based Nutrition
2016Hong Kong College of PhysiciansFHKCP
2016Hong Kong Academy of MedicineFHKAM (Medicine)
2017Royal Society for Public HealthFRSPH
Biography

ACADEMIC QUALIFICATIONS

  • 2017                   Fellowship of the Royal Society for Public Health (FRSPH)
  • 2016                   Fellowship of the Hong Kong Academy of Medicine (FHKAM [Medicine])
  • 2016                   Fellowship of the Hong Kong College of Physicians (FHKCP)
  • 2015                   Certificate in Plant-Based Nutrition (Cornell University, USA)
  • 2010                   Fellowship of the Royal College of Physicians of London (FRCP Lond)
  • 2009                   Fellowship of the Royal College of Physicians of Edinburgh (FRCP Edin)
  • 2006                   Postgraduate Diploma in Clinical Neurology with Distinction (UCL London, UK)
  • 2002                   Doctor of Medicine (MD, University of Edinburgh, UK)
  • 2000                   Master of Philosophy (MPhil, University of Southampton, UK)
  • 1997                   Membership of the Royal College of Physician (MRCP UK)
  • 1994                   MB ChB (University of Bristol, UK)

CLINICAL ACADEMIC POSITIONS

  • 2017-now           Member, Bau Institite of Medical & Health Sciences Education
  • 2017-now           Specality Board Member for Geriatric Medicine, HK College of Physicians
  • 2016                   Visiting Scholar, UCSF Memory and Aging Center, San Francisco, USA          
  • 2015-now           Director, Gerontology Research Laboratory, Department of Medicine, HKU
  • 2014-now           Clinical Associate Professor in Geriatric Medicine, Department of Medicine, HKU
  • 2014-2015          Clinical teacher, Neurological Diseases Unit, HKU-Shenzhen Hospital, Shenzhen, China
  • 2010-2012          Head of Department, Stroke Medicine, Royal Bournemouth Hospital, UK
  • 2009-2011          Regional Medical Director for Stroke Service, Dorset, UK
  • 2006-2013          Consultant Physician in Gerontology, Stroke & Internal Medicine, Royal Bournemouth Hospital, UK
  • 2006                   Neurology Fellow, Insitute of Neurology, Queen Square, UK
  • 2002-2006          Post-doctoral Clinical & Research Trainee in Internal & Geriatric Medicine (University of Southampton, UK)
  • 2001-2002          Stroke Association Clinical training/Research Fellow (MD, University of Edinbuirgh, UK)
  • 2000-2001          Glaxo Wellcome Stroke Clinical training/Research Fellow (MD, University of Edinbuirgh, UK)
  • 1998-2000          Research Fellow in Stroke Medicine (MPhil, University of Southampton, UK)

HONORARY POSITIONS

  • 2014-now           Honorary Research Fellow, Sau Po Centre on Ageing, The University of Hong Kong, HK
  • 2014-now           Honorary Clinical Associate Professor, Department of Family Medicine & Primary Care, HKU
  • 2014-now           Honorary Consultant Gerontologist, Department of Medicine, Queen Mary Hospital, HK
  • 2014-now           Honorary Consultant Gerontologist, Department of Medicine, Grantham Hospital, HK
  • 2008-now           Visiting Professor, Bournemouth University, UK
  • 2006-2013          Honorary Senior Clinical Lecturer, Southampton University, UK

RESEARCH FUNDING PORTFOLIO

  • 2017            Google Scholar: h-index 27 i-10-index 36
  • 2017            Boehringer-Ingelheim Ltd. donation: Integrative AF Treatment Pathway for Elderly AF Patients (PI, $200K)
  • 2017            Liu Po Shan Endowment Fund for Motor Neuron Disease: new registry of FTD/MND cohort (PI, $200K)
  • 2017            HK Jockey Club Charities Trust: Persoanlised, Holistic Integrative Rehab Care (Advisor, HKSR, $140M)
  • 2017            RGC GRF ($936K): Video-supported nurse-led advance care planning in frail geriatric patients (Co-I, $936K)
  • 2017            Food & Health Bureau: Evaluation Study of Service for Dementia Community Support Scheme (Co-I, $1.38M)
  • 2017            Novartis Ltd. research donation - HKU Memory Clinic Registry (PI, $200K)
  • 2017            Pfizer Ltd. research donation - MRI of heart and brain in patients with atrial fibrillation (PI, $200K)
  • 2017            Seed Fund (HKU) - Zebrafish as a model to investigate the biological effects of exercise (PI, $56K)
  • 2016-now    QMH TRAS: Benefit to the older people who train and work as exercise coaches (PI, $50K)
  • 2016-now    Prenetics Ltd. research donation - Genetic determination of response to dementia drugs (PI, $100K)
  • 2016-now    Lee Hysan Foundation: Carer stress after stroke (Co-I)
  • 2016-now    SY Lee Foundation: GrandMove and GrandMove Plus Studies (Co-I)
  • 2016-now    HMRF: Advance care planning in older people (Co-A)
  • 2015-now    GRF: Neurobiology of cerebral aging (Co-I)
  • 2015-now    Seed Fund for Collaborative Research (HKU): Visual impairment in Alzheimer's disease (Co-PI, $100K)
  • 2015-now    Seed Fund for Collaborative Research (HKU): Cancer care in older people: geri-oncology (Co-PI, $100K)
  • 2015-now    Seed Fund for Collaborative Research (HKU): Cognitive reserve and neuroplasticity in aging (Co-PI, $100K)
  • 2015-now    Development Fund for Medical Humanities (HKU) - Humanism in Aging (PI, $100K)
  • 2014-now    Seed Fund (HKU) - Multimodal comparison study of vascular dementia vs Alzheimer's disease (PI, $120K)
  • 2014-now    Boehringer-Ingelheim Ltd. donation - MRI correlates of cerebrovascular disease and patient outcome (PI, $200K)
  • 2014-now    Start-up Fund (HKU) - Clinical correlates of cerebral microbleeds and white matter ischaemia on MRI (PI, $300K)

MEDICAL RESEARCH - ONGOING PROJECTS

1) Dementia

  • Formal linkage of HKU Neurocognitive Disorders Cohort to the Dementias Platform UK (PI)
  • HKU Neurocognitive Disorders Cohort – prospective study of patients with subjective cognitive decline & mild cognitive impairment (PI)
  • HKU Memory Clinic Registry – retrospective study of all HKU Memory Clinic patients since 2002 (PI, Novartis Ltd.)
  • Improving the quality of life for nursing home residents with dementia (PI, Advisor for Project PHI, HKJC Charitable Trust)
  • FTD/MND in Hong Kong (PI, Liu Po Shan Endowment Fund)
  • Neuroimaging study of cerebral ageing (Co-I, GRF)
  • High definition EEG (Event-Response Potential) as a biomarker for pathological subjective cognitive decline (PI, MPhil)
  • Amyloid PET (F18 Flutametamol) vs. MRI in Alzheimer's disease and vascular dementia (Co-I)
  • Micro-RNA biomarkers in dementia (Co-I)
  • Microvesicles as biomarkers of dementia (PI)
  • Genetic determination of response to cholinesterase inhibitors in patients with Alzheimer's Disease (PI, Prenetics Ltd.)
  • Genetic determination of response to antipsychotic medications in patients with dementia/behavioural and psychiatric symptoms (PI, Prenetics Ltd.)
  • Computerised assessment of brain function in aging and dementia – laptop and tablet-based tools (PI)
  • Bilingualism for cerebral protection in patients with mild cognitive impairment (PI)
  • Validation of the Oxford Cognitive Screen - Plus (OCS-P) tool (Co-I)
  • Association between depressive mood and memory decline in community dwelling adults (PI)
  • Expressive art therapy for dementia and delirium (Co-I)
  • Eye movement tracking as an early biomarker for dementia (Co-I)
  • Retinal thickness as an early biomarker for dementia (Co-I, CRF Seed)
  • Cognitive function and effective use of eye drops (Co-I)
  • Cognitive reserve and retirement (Co-I, CRF Seed)
  • Carer stress in dementia patients with dementia/behavioural and psychiatric symptoms (PI)
  • Evaluation study of dementia community support scheme (Co-I, Food and Health Bureau)
  • Comparisons of MMSE and HK-MOCA in an older Chinese population (Co-I)

2) Heart and brain

  • HKU Elderly AF Treatment Registry – prospective study of older patients with atrial fibrillation (PI, Boehringer-Ingelheim Ltd.)
  • Development of new-onset dementia in patients with atrial fibrillation (Co-I)
  • Prospective study of cognitive decline in older patients with atrial fibrillation (PI)
  • MRI of heart and brain in patients with atrial fibrillation (PI, Pfizer Ltd.)
  • Optimal treatment pathway of atrial fibrillation in older people (PI)
  • AF screening in the high risk elderly population (Co-I)

3) Stroke / small vessel disease

  • MRI makers of small vessel disease as predictors of cognitive decline in subjective cognitive decline & mild cognitive impairment (PI)
  • MRI makers of small vessel disease as predictors of outcome after stroke rehabilitation (PI)
  • MRI-derived structural connectivity as a predictor of outcome after stroke rehabilitation (Co-I)
  • Cochrane review of anti-thrombotic agents to prevent dementia in patients with small vessel disease on MRI (PI)
  • Cochrane review of anti-epileptic drugs to prevent seizures after stroke (PI)
  • Cochrane review of anti-epileptic drugs to prevent seizures after subarachnoid haemorrhage (PI)
  • Cochrane review of anti-epileptic drugs to prevent seizures after intracranial venous thrombosis (PI)
  • Transcranial Direct Current Stimulation (tDCS) for dysarthria after stroke (Co-I)
  • We-Rise Project on carer stress after stroke (Co-I, Lee Hysan Foundation)

4) Frailty and sarcopenia

  • Intensive rehabilitation to prevent and reverse frailty (PI, Advisor for Project PHI, HKJC Charitable Trust)
  • Frailty and sarcopenia in older people with AF (PI)
  • Frailty and sarcopenia in patients with SCD, MCI and dementia (PI)
  • Frailty in older community dwelling adults in Hong Kong (Co-I)
  • Frailty and its clinical consequence in Old Age Homes in Hong Kong (Co-I)
  • Study of Centenarians in Hong Kong (Co-I)
  • Tanner Hill Project of frailty prevention in older people (Co-I)
  • SEN Project of frailty prevention in older people (Co-I)
  • Impact of frailty on the selection and outcome of patients for cardiothoracic surgery (Co-I)
  • Impact of frailty on the selection and outcome of patients for breast cancer treatments (Co-I)
  • Hong Kong Society on Rehabilitation Project of intensive rehabilitation to treat physical and cognitive frailty (Co-I, Jockey Club)
  • Outcome study of older people with intellectual disability in Hong Kong (Co-I)
  • Contractures and their impact on old age home residents (PI, Inter-RAI)

5) Exercise

  • Zebrafish as a model to investigate the biological effects of exercise (PI, PhD)
  • Zebrafish as a model to evaluate autophagy in aging and exercise (PI, PhD)
  • GrandMove – randomised controlled trial of exercise intervention for community dwelling older people (Co-I, SY Lee Foundation)
  • GrandMove Plus – randomised controlled trial of exercise intervention for frail old age home residents (Co-I, SY Lee Foundation)
  • Benefit to the older people who train and work as exercise coaches (PI, QMH TRAS funding)

6) End of life and ethics

  • Advanced Care Planning education for the public (Co-I, HMRF)
  • End of life pathway in the acute hospital (Co-I)
  • Use of restraints and its impact in old age homes (PI, Inter-RAI)
 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Chan, FHW
Yau, SZM
2015-01-01Curriculum Development Fund for Medical Humanities "Humanism in Aging: Intergenerational and Experiential Learning in the Community": HKU Li Ka Shing Faculty of Medicine
Research Achievement
2011-07-01"Excellence in Practice National Team of the Year” Award: Arrhythmia Alliance, UK
Others
2002-07-01MD Thesis: "Integrated Care Pathways for Acute Stroke": University of Edinburgh
Research Achievement
2014-03-01Start Up Grant: "Study on the interaction between vascular risk factors, MRI, cognition and outcome": Department of Medicine, HKU
Research Achievement
2009-07-01“Innovative Health and Social Care Technology” Award: NHS South West of England, UK
Others
2001-01-01Stroke Association Clinical Training Fellowship (Edinburgh University): The Stroke Association, UK
Research Achievement
2000-01-01Best oral presentation prize at BASP Annual Scientific Conference: British Association of Stroke Physicians, UK
Research Achievement
2000-07-01MPhil Thesis: "Recovery of cerebral autoregulation during the first three months after acute ischaemic stroke – a longitudinal study using transcranial Doppler ultrasonography": University of Southampton
Research Achievement
2001-01-01Glaxo Wellcome Clinical Training Fellowship (Edinburgh University): Glaxo Wellcome
Research Achievement
2006-03-01Pat Harris Prize (Postgraduate Diploma in Clinical Neurology with Distinction, top student): University College London, UK
Others
2015-06-01Dr Ng Ngai-sing Prize For Outstanding Free Paper Presentation (Annual Scientific Meeting 2015): Hong Kong Geriatrics Society
Research Achievement
Chu, LW
Chan, HWF
2014-07-01Seed Funding: "Multimodal comparison study of vascular dementia vs. Alzheimer's disease" ($120K): The University of Hong Kong
Research Achievement
Chang, SKR
Doherty, I
Hon, SFK
Lee, R
Mak, W
2014-10-01ePoster Award (First Prize, Frontiers Series – East-West Alliance Global Symposia): "Establishing an eLearning Platform in Clinical Neurosciences at HKU": HKU Li Ka Shing Faculty of Medicine
Teaching Accomplishment
2016-05-01HKU Overseas Fellowship Award 2016-7 (UCSF Memory & Aging Center Overseas Scholarship): The University of Hong Kong
Research Achievement
2015-06-01Outstanding Investigator Award (1st Runner Up, International Alzheimer’s Disease Conference 2015): The University of Hong Kong
Research Achievement
2016-07-01Research Donation: "Genetic determination of responses to dementia drugs in patients with Alzheimer's Disease, and to antipsychotic drugs in patients with BPSD": Prenetics Ltd.
Research Achievement
2015-10-01Seed Fund for Collaborative Research: Visual impairment in Alzheimer's disease (Co-PI, $100K): The University of Hong Kong
Research Achievement
2015-10-01Seed Fund for Collaborative Research: Cognitive reserve and neuroplasticity in aging (Co-PI, $100K): The University of Hong Kong
Research Achievement
Leung, DYP
Chan, FHW
Chiu, PKC
2015-11-01Measuring self-efficacy for caregiving of caregivers of patients with palliative care needs: Validating of the Caregiver Inventory (Co-A, $259K): HMRF, Food & Health Bureau
Research Achievement
2017-01-01Seed Funding: "Effects of exercise on aging" ($56K): The University of Hong Kong
Research Achievement
Tse, MA
2017-01-01Benefit to the older people who train and work as exercise coaches (PI, $50K): Queen Mary Hospital Training & Research Assistance Scheme
Research Achievement
David, D
2016-12-01UCL Global Engagement Fund (Collaborator, £2000): University College London
Others
2015-10-01Seed Fund for Collaborative Research: Cancer care in older people (Geri-Oncology) (Co-PI, $100K): The University of Hong Kong
Research Achievement
Leung, DYP
Chiu, P
Chan, FHW
Yau, S
2017-04-01Video-supported nurse-led advance care planning in frail geriatric patients (Co-A, $936K): RGC GRF
Research Achievement
2017-04-01Evaluation Study of Service for Dementia Community Support Scheme (Co-I, $1.4M): Food & Health Bureau
Research Achievement
2017-08-01Frontotemporal Degeneration with Motor Neuron Disease (FTD/MND) in Chinese people (PI, $200K): Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron Disease
Research Achievement
Chan, H
Leung, AYM
Lai, C
Leung, P
Chau, P
Tse, MA
Pang, M
2017-08-01Personalized, Holistic & Intensive Rehabilitation Care for Frailty and Dementia (Steering Group, HKSR, $141M): Hong Kong Jockey Club Charitable Trust
Research Achievement
Leung, AYM
2015-04-01Training Grandma/pa - Robustness against Frailty - Healthy Ageing x Productive Ageing Project (Co-I, $5.3M): Simon KY Lee Foundation
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
06/2014-MemberAsian Working Group for Sarcopenia
06/2016-Chief Examiner for English ProficiencyHong Kong Medical Council
01/2014-MemberHKU Alzheimer's Disease Research
06/2017-MemberHKCP - Geriatric Medicine Specialty Board
01/2014-InvestigatorHKU Heart, Brain, Hormone and Healthy Ageing Centre
01/2014-MemberAmerican Geriatrics Society
01/2000-2013MemberBritish Association of Stroke Physicians
01/1998-MemberBritish Geriatrics Society
01/2006-2013MemberBritish Society for Research on Ageing
12/2015-MemberChinese Dementia Research Association
01/2014-MemberHK Geriatrics Society
01/2006-2013MemberQueen Square Alumnus Association
Major Research Themes & Current Projects
DescriptionTitle
Principle Investigator - prospective cohort of patients with dementia, mild cognitive impairment (MCI) and Subjective Cognitive Decline (SCD), internationally linked to NACC (USA) and Dementia Platforms UKHKU Neurocognitive Disorder Cohort
Principle InvestigatorHKU Elderly Atrial Fibrillation Treatment Registry
Principle InvestigatorHKU Memory Clinic Registry
Principle InvestigatorMRI and Stroke Rehabilitation Outcomes
Principle InvestigatorGenetic determination of response to cholinesterase inhibitors in patients with Alzheimer's Disease
Principle InvestigatorHigh definition EEG (Event-Response Potential) Biomarkers in Dementia
Principle InvestigatorGenetic Determinants of Response to Antipsychotic Medications in Patients with Dementia
Media Contact Directory
Area of Expertise:
Area of Expertise (EN)Area of Expertise (ZH)
Dementia
Stroke
Aging
Geriatric Medicine
Spoken Languages:
Spoken Language(s) (EN)Spoken Language(s) (ZH)
English
Cantonese
Written Languages:
Written Language(s) (EN)Written Language(s) (ZH)
English
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