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  Patent History
  • Application
    US 09/010227 2001-12-06
  • Publication
    US 2003143657 2003-07-31
  Patent Family
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published patent: Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics

TitleMethods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
Priority Date2001-12-06 US 09/010227
Inventors
Hamer LisbethAdachi KiichiDezwaan ToddLo, CSCFrank SherylDarveaux BlaiseMahanty SanjoyHeiniger RyanSkalchunes AmyPan HuaqinTarpey RexShuster JeffreyTanzer Matthew M
Issue Date2003
Citation
US Published patent application US 2003143657. Washington, DC: US Patent and Trademark Office (USPTO), 2003 How to Cite?
AbstractThe present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Persistent Identifierhttp://hdl.handle.net/10722/176843

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:34Z-
dc.date.available2012-11-30T08:38:34Z-
dc.date.issued2003-
dc.identifier.citationUS Published patent application US 2003143657. Washington, DC: US Patent and Trademark Office (USPTO), 2003en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176843-
dc.description.abstractThe present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.en_HK
dc.titleMethods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibioticsen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorHamer Lisbethen_HK
dc.contributor.inventorAdachi Kiichien_HK
dc.contributor.inventorDezwaan Todden_HK
dc.contributor.inventorLo, CSCen_HK
dc.contributor.inventorFrank Sherylen_HK
dc.contributor.inventorDarveaux Blaiseen_HK
dc.contributor.inventorMahanty Sanjoyen_HK
dc.contributor.inventorHeiniger Ryanen_HK
dc.contributor.inventorSkalchunes Amyen_HK
dc.contributor.inventorPan Huaqinen_HK
dc.contributor.inventorTarpey Rexen_HK
dc.contributor.inventorShuster Jeffreyen_HK
dc.contributor.inventorTanzer Matthew Men_HK
patents.identifier.applicationUS 09/010227en_HK
patents.description.assigneeHAMER LISBETH, ; ADACHI KIICHI, ; DEZWAAN TODD, ; LO SZE-CHUNG, ; MONTENEGRO-CHAMORRO MARIA VICTORIA, ; FRANK SHERYL, ; DARVEAUX BLAISE, ; MAHANTY SANJOY, ; HEINIGER RYAN, ; SKALCHUNES AMY, ; PAN HUAQIN, ; TARPEY REX, ; SHUSTER JEFFREY, ; TANZER MATTHEW M, ; PARADIGM GENETICS, INCen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2003-07-31en_HK
patents.date.application2001-12-06en_HK
patents.date.priority2001-12-06 US 09/010227en_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2003143657en_HK
patents.relation.familyAU 2002363978 (A1) 2003-06-23en_HK
patents.relation.familyCA 2469695 (A1) 2003-06-19en_HK
patents.relation.familyEP 1461460 (A2) 2004-09-29en_HK
patents.relation.familyJP 2005524390 (A) 2005-08-18en_HK
patents.relation.familyUS 2003124642 (A1) 2003-07-03en_HK
patents.relation.familyUS 6689578 (B2) 2004-02-10en_HK
patents.relation.familyUS 2003143657 (A1) 2003-07-31en_HK
patents.relation.familyUS 6733963 (B2) 2004-05-11en_HK
patents.relation.familyUS 2003148412 (A1) 2003-08-07en_HK
patents.relation.familyUS 6740498 (B2) 2004-05-25en_HK
patents.relation.familyUS 2003108979 (A1) 2003-06-12en_HK
patents.relation.familyUS 6806060 (B2) 2004-10-19en_HK
patents.relation.familyUS 2003186837 (A1) 2003-10-02en_HK
patents.relation.familyUS 6852484 (B2) 2005-02-08en_HK
patents.relation.familyWO 03050310 (A2) 2003-06-19en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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