granted patent: Bioengineered Intervertebral Discs and Methods for Their Preparation

TitleBioengineered Intervertebral Discs and Methods for Their Preparation
Granted PatentUS 20070292514
US 8734827
Granted Date2007-12-20
Priority Date2007-04-30 US 11/742040
2006-04-28 US 11/796088P
Inventors
Issue Date2007
Citation
US Patent US 20070292514. Washington, DC: US Patent and Trademark Office (USPTO), 2007 How to Cite?
AbstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density mechanical property and stability, etc.; The extent of the change i volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.
Persistent Identifierhttp://hdl.handle.net/10722/208123

 

DC FieldValueLanguage
dc.date.accessioned2015-02-12T04:37:55Z-
dc.date.available2015-02-12T04:37:55Z-
dc.date.issued2007en_US
dc.identifier.citationUS Patent US 20070292514. Washington, DC: US Patent and Trademark Office (USPTO), 2007en_US
dc.identifier.urihttp://hdl.handle.net/10722/208123-
dc.description.abstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density mechanical property and stability, etc.; The extent of the change i volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.en_US
dc.relation.isreferencedbyWO 2014167310 (A1) 2014-10-16en_US
dc.relation.isreferencedbyUS 2014008545 (A1) 2014-01-09en_US
dc.relation.isreferencedbyUS 2012148537 (A1) 2012-06-14en_US
dc.relation.isreferencedbyUS 2011177132 (A1) 2011-07-21en_US
dc.relation.isreferencedbyUS 8603819 (B2) 2013-12-10en_US
dc.relation.isreferencedbyUS 2011040279 (A1) 2011-02-17en_US
dc.relation.isreferencedbyUS 8926552 (B2) 2015-01-06en_US
dc.relation.isreferencedbyWO 2009142770 (A2) 2009-11-26en_US
dc.relation.isreferencedbyWO 2009142770 (A3) 2010-01-14en_US
dc.relation.isreferencedbyUS 2008031858 (A1) 2008-02-07en_US
dc.relation.isreferencedbyUS 8679809 (B2) 2014-03-25en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleBioengineered Intervertebral Discs and Methods for Their Preparationen_US
dc.typePatenten_US
dc.identifier.authorityCHAN PUI BARBARA=rp00087en_US
dc.identifier.authorityCHEUNG KENNETH M=rp00387en_US
dc.identifier.authorityCHAN DANNY=rp00540en_US
dc.identifier.authorityCHAN GODFREY C=rp00431en_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChan, BPen_US
dc.contributor.inventorCheung, KMCen_US
dc.contributor.inventorChan, Den_US
dc.contributor.inventorChan, GCFen_US
dc.contributor.inventorHui, TYen_US
patents.identifier.applicationUS 11/742040en_US
patents.identifier.grantedUS 20070292514en_US
patents.identifier.grantedUS 8734827-
patents.description.assigneeUNIV HONG KONGen_US
patents.description.countryUnited States of Americaen_US
patents.date.granted2007-12-20en_US
patents.identifier.hkutechidME-2006-00207-1-
patents.date.application2007-04-30en_US
patents.date.priority2007-04-30 US 11/742040en_US
patents.date.priority2006-04-28 US 11/796088Pen_US
patents.description.ccusen_US
patents.relation.familyUS 8734827 (B2) 2014-05-27en_US
patents.relation.familyCN 101478934 (A) 2009-07-08en_US
patents.relation.familyEP 2019653 (A2) 2009-02-04en_US
patents.relation.familyWO 2008078157 (A2) 2008-07-03en_US
patents.description.kindA1en_US
patents.typePatent_granteden_US

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