published patent: BIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATION

TitleBIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATION
Priority Date2006-04-28 US 11/796088P
Inventors
Issue Date2008
Citation
WO Published patent application WO 2008078157. World Intellectual Property Organization (WIPO), PatentScope, 2008 How to Cite?
AbstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density, mechanical property and stability, etc.; The extent of the change in volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.
Persistent Identifierhttp://hdl.handle.net/10722/177127
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:11Z-
dc.date.available2012-11-30T08:39:11Z-
dc.date.issued2008-
dc.identifier.citationWO Published patent application WO 2008078157. World Intellectual Property Organization (WIPO), PatentScope, 2008en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177127-
dc.description.abstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density, mechanical property and stability, etc.; The extent of the change in volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.en_HK
dc.relation.isreferencedbyWO 2009007979 (A2) 2009-01-15en_HK
dc.relation.isreferencedbyWO 2009007979 (A3) 2009-03-05en_HK
dc.relation.isreferencedbyEP 2021035 (A2) 2009-02-11en_HK
dc.relation.isreferencedbyEP 2021035 (A4) 2010-08-25en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleBIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorCheung, KMCen_HK
dc.contributor.inventorChan, Den_HK
dc.contributor.inventorChan, GCFen_HK
dc.contributor.inventorHui, Ting, Yanen_HK
patents.identifier.applicationPC T/IB2007003272en_HK
patents.description.assigneeUNIV HONG KONG [CN]; CHAN BARBARA PUI [CN]; CHEUNG KENNETH MAN CHEE [CN]; CHAN DANNY [CN]; CHAN GODFREY CHI-FUNG [CN]; HUI TING YAN [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2008-07-03en_HK
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patents.date.application2007-04-30en_HK
patents.date.priority2006-04-28 US 11/796088Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2008078157en_HK
patents.relation.familyCN 101478934 (A) 2009-07-08en_HK
patents.relation.familyEP 2019653 (A2) 2009-02-04en_HK
patents.relation.familyUS 2007292514 (A1) 2007-12-20en_HK
patents.relation.familyWO 2008078157 (A2) 2008-07-03en_HK
patents.description.kindA2en_HK
patents.typePatent_publisheden_HK

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