published patent: BIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATION

TitleBIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATION
Priority Date2007-04-30 PCT/IB2007003272
2006-04-28 US 11/796088P
Inventors
Issue Date2009
Citation
EP Published Patent application EP 2019653. European Patent Office (EPO), Escapenet, 2009 How to Cite?
AbstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density mechanical property and stability, etc. The extent of the change i volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.
Persistent Identifierhttp://hdl.handle.net/10722/176751
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:26Z-
dc.date.available2012-11-30T08:38:26Z-
dc.date.issued2009-
dc.identifier.citationEP Published Patent application EP 2019653. European Patent Office (EPO), Escapenet, 2009en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176751-
dc.description.abstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density mechanical property and stability, etc. The extent of the change i volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleBIOENGINEERED INTERVERTEBRAL DISCS AND METHODS FOR THEIR PREPARATIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorCheung, KMCen_HK
dc.contributor.inventorChan, Den_HK
dc.contributor.inventorChan, GCFen_HK
dc.contributor.inventorHui, Ting, Yanen_HK
patents.identifier.applicationEP 20070872042en_HK
patents.description.assigneeUNIV HONG KONG [CN]en_HK
patents.description.countryEuropean Patent Officeen_HK
patents.date.publication2009-02-04en_HK
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patents.date.application2007-04-30en_HK
patents.date.priority2007-04-30 PCT/IB2007003272en_HK
patents.date.priority2006-04-28 US 11/796088Pen_HK
patents.description.ccEPen_HK
patents.identifier.publicationEP 2019653en_HK
patents.relation.familyCN 101478934 (A) 2009-07-08en_HK
patents.relation.familyEP 2019653 (A2) 2009-02-04en_HK
patents.relation.familyUS 2007292514 (A1) 2007-12-20en_HK
patents.relation.familyWO 2008078157 (A2) 2008-07-03en_HK
patents.description.kindA2en_HK
patents.typePatent_publisheden_HK

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