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  Patent History
  • Application
    CN 20078022790 2007-04-30
  • Publication
    CN 101478934 2009-07-08

published patent: Bioengineered intervertebral discs and methods for their preparation

TitleBioengineered intervertebral discs and methods for their preparation
Priority Date2007-04-30 PCT/IB2007003272
2006-04-28 US 11/796088P
Inventors
Issue Date2009
Citation
China Published Patent Application CN 101478934. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2009 How to Cite?
AbstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density mechanical property and stability, etc.; The extent of the change i volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.
Persistent Identifierhttp://hdl.handle.net/10722/176621

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:15Z-
dc.date.available2012-11-30T08:38:15Z-
dc.date.issued2009-
dc.identifier.citationChina Published Patent Application CN 101478934. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2009en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176621-
dc.description.abstractA bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density mechanical property and stability, etc.; The extent of the change i volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleBioengineered intervertebral discs and methods for their preparationen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorCheung, KMCen_HK
dc.contributor.inventorChan, Den_HK
dc.contributor.inventorHui Ting Yanen_HK
patents.identifier.applicationCN 20078022790en_HK
patents.identifier.applicationZL200780022790.1-
patents.description.assigneeUNIV HONG KONG [HK]en_HK
patents.description.countryChina, PRCen_HK
patents.date.publication2009-07-08en_HK
patents.identifier.hkutechidME-2006-00207-2-
patents.date.application2007-04-30en_HK
patents.date.priority2007-04-30 PCT/IB2007003272en_HK
patents.date.priority2006-04-28 US 11/796088Pen_HK
patents.description.ccCNen_HK
patents.identifier.publicationCN 101478934en_HK
patents.relation.familyCN 101478934 (A) 2009-07-08en_HK
patents.relation.familyEP 2019653 (A2) 2009-02-04en_HK
patents.relation.familyUS 2007292514 (A1) 2007-12-20en_HK
patents.relation.familyWO 2008078157 (A2) 2008-07-03en_HK
patents.description.kindAen_HK
patents.typePatent_publisheden_HK

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