published patent: METHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION

TitleMETHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION
Priority Date1995-08-22 US 08/002621P
Inventors
Issue Date1997
Citation
WO Published patent application WO 9708292. World Intellectual Property Organization (WIPO), PatentScope, 1997 How to Cite?
AbstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/177164
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:16Z-
dc.date.available2012-11-30T08:39:16Z-
dc.date.issued1997-
dc.identifier.citationWO Published patent application WO 9708292. World Intellectual Property Organization (WIPO), PatentScope, 1997en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177164-
dc.description.abstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.en_HK
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dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLau, ASYen_HK
patents.identifier.applicationPC T/US1996013745en_HK
patents.description.assigneeUNIV CALIFORNIA [US]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication1997-03-06en_HK
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patents.date.application1996-08-22en_HK
patents.date.priority1995-08-22 US 08/002621Pen_HK
patents.description.ccWOen_HK
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patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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