published patent: METHODS FOR ENHANCING THE PRODUCTION OF INTERFERON IN CELL CULTURE

TitleMETHODS FOR ENHANCING THE PRODUCTION OF INTERFERON IN CELL CULTURE
Priority Date1996-08-22 PCT/US1996013627
1995-08-22 US 08/002621P
Inventors
Issue Date1998
Citation
EP Published Patent application EP 0846174. European Patent Office (EPO), Escapenet, 1998 How to Cite?
AbstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/176723
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:24Z-
dc.date.available2012-11-30T08:38:24Z-
dc.date.issued1998-
dc.identifier.citationEP Published Patent application EP 0846174. European Patent Office (EPO), Escapenet, 1998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176723-
dc.description.abstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR ENHANCING THE PRODUCTION OF INTERFERON IN CELL CULTUREen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorLau, ASYen_HK
patents.identifier.applicationEP 19960929017en_HK
patents.description.assigneeUNIV CALIFORNIA [US]en_HK
patents.description.countryEuropean Patent Officeen_HK
patents.date.publication1998-06-10en_HK
dc.relation.referencesXP 001061758en_HK
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patents.date.application1996-08-22en_HK
patents.date.priority1996-08-22 PCT/US1996013627en_HK
patents.date.priority1995-08-22 US 08/002621Pen_HK
patents.description.ccEPen_HK
patents.identifier.publicationEP 0846174en_HK
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patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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