published patent: METHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION

TitleMETHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSION
Priority Date1995-08-22 US 08/002621P
1996-08-22 PCT/US1996013745
Inventors
Issue Date1999
Citation
Brazil Published Patent Application BR 9610550. Brazil: Brazil Patent Office, 1999 How to Cite?
AbstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/176563

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:07Z-
dc.date.available2012-11-30T08:38:07Z-
dc.date.issued1999-
dc.identifier.citationBrazil Published Patent Application BR 9610550. Brazil: Brazil Patent Office, 1999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176563-
dc.description.abstractMethods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR ENHANCING THE PRODUCTION OF VIRAL VACCINES IN CELL CULTURE BY INTERFERON SUPPRESSIONen_HK
dc.typePatenten_US
dc.contributor.inventorLau, ASYen_HK
patents.identifier.applicationBR 19960010550en_HK
patents.description.assigneeUNIV CALIFORNIA [US]en_HK
patents.description.countryBrazilen_HK
patents.date.publication1999-07-06en_HK
patents.date.application1996-08-22en_HK
patents.date.priority1995-08-22 US 08/002621Pen_HK
patents.date.priority1996-08-22 PCT/US1996013745en_HK
patents.description.ccBRen_HK
patents.identifier.publicationBR 9610550en_HK
patents.relation.familyAT 289348 (T) 2005-03-15en_HK
patents.relation.familyAU 6860896 (A) 1997-03-19en_HK
patents.relation.familyAU 707130 (B2) 1999-07-01en_HK
patents.relation.familyAU 6857696 (A) 1997-03-19en_HK
patents.relation.familyBR 9610550 (A) 1999-07-06en_HK
patents.relation.familyCA 2229163 (A1) 1997-03-06en_HK
patents.relation.familyCA 2229405 (A1) 1997-03-06en_HK
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patents.relation.familyCN 1161469 (C) 2004-08-11en_HK
patents.relation.familyDE 69634360 (T2) 2005-12-29en_HK
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patents.relation.familyJP H11511324 (A) 1999-10-05en_HK
patents.relation.familyJP 3432519 (B2) 2003-08-04en_HK
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patents.relation.familyUS 2001055791 (A1) 2001-12-27en_HK
patents.relation.familyUS 6855519 (B2) 2005-02-15en_HK
patents.relation.familyUS 2004157310 (A1) 2004-08-12en_HK
patents.relation.familyUS 7132271 (B2) 2006-11-07en_HK
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patents.relation.familyWO 9708292 (A1) 1997-03-06en_HK
patents.relation.familyWO 9708324 (A1) 1997-03-06en_HK
patents.description.kindAen_HK
patents.typePatent_publisheden_HK

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