published patent: Chimeric antisense oligonucleotides of arabinofuranose analogue and deoxyribose nucleotides

TitleChimeric antisense oligonucleotides of arabinofuranose analogue and deoxyribose nucleotides
Priority Date2001-09-04 PCT/CA2001001252
2000-09-06 US 09/230414P
Inventors
Issue Date2004
Citation
US Published patent application US 2004038399. Washington, DC: US Patent and Trademark Office (USPTO), 2004 How to Cite?
AbstractThe present invention relates to novel oligonucleotide chimera used as therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention is directed to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length. Particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc.; More particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to and induce cleavage of (via RNaseH activation) the complementary RNA.
Persistent Identifierhttp://hdl.handle.net/10722/176861

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:36Z-
dc.date.available2012-11-30T08:38:36Z-
dc.date.issued2004-
dc.identifier.citationUS Published patent application US 2004038399. Washington, DC: US Patent and Trademark Office (USPTO), 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176861-
dc.description.abstractThe present invention relates to novel oligonucleotide chimera used as therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention is directed to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length. Particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc.; More particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to and induce cleavage of (via RNaseH activation) the complementary RNA.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleChimeric antisense oligonucleotides of arabinofuranose analogue and deoxyribose nucleotidesen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorDamha Masad Joseen_HK
dc.contributor.inventorParniak Michael Aen_HK
dc.contributor.inventorLok, CNen_HK
dc.contributor.inventorViazovkina Ekaterinaen_HK
patents.identifier.applicationUS 10/363768en_HK
patents.description.assigneeDAMHA MASAD JOSE, ; PARNIAK MICHAEL A, ; LOK CHUN-NAM, ; VIAZOVKINA EKATERINA, ; MCGILL UNIVERSITYen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2004-02-26en_HK
patents.date.application2003-06-13en_HK
patents.date.priority2001-09-04 PCT/CA2001001252en_HK
patents.date.priority2000-09-06 US 09/230414Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2004038399en_HK
patents.relation.familyAT 293688 (T) 2005-05-15en_HK
patents.relation.familyAU 8944801 (A) 2002-03-22en_HK
patents.relation.familyAU 2001289448 (B2) 2006-03-16en_HK
patents.relation.familyCA 2419563 (A1) 2002-03-14en_HK
patents.relation.familyDE 60110244 (T2) 2006-01-19en_HK
patents.relation.familyEP 1315807 (A2) 2003-06-04en_HK
patents.relation.familyJP 2004507272 (A) 2004-03-11en_HK
patents.relation.familyUS 2004038399 (A1) 2004-02-26en_HK
patents.relation.familyUS 8178348 (B2) 2012-05-15en_HK
patents.relation.familyWO 0220773 (A2) 2002-03-14en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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