published patent: CHIMERIC ANTISENSE OLIGONUCLEOTIDES OF ARABINOFURANOSE ANALOGUES AND DEOXYRIBOSE NUCLEOTIDES

TitleCHIMERIC ANTISENSE OLIGONUCLEOTIDES OF ARABINOFURANOSE ANALOGUES AND DEOXYRIBOSE NUCLEOTIDES
Priority Date2001-09-04 PCT/CA2001001252
2000-09-06 US 09/230414P
Inventors
Issue Date2002
Citation
Canada Published Patent Application CA 2419563. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2002 How to Cite?
AbstractThe present invention relates to novel oligonucleotide chimera used as therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention is directed to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length. Particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc. More particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to and indu ce cleavage of (via RNaseH activation) the complementary RNA.
Persistent Identifierhttp://hdl.handle.net/10722/176575

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:08Z-
dc.date.available2012-11-30T08:38:08Z-
dc.date.issued2002-
dc.identifier.citationCanada Published Patent Application CA 2419563. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176575-
dc.description.abstractThe present invention relates to novel oligonucleotide chimera used as therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention is directed to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length. Particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc. More particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to and indu ce cleavage of (via RNaseH activation) the complementary RNA.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleCHIMERIC ANTISENSE OLIGONUCLEOTIDES OF ARABINOFURANOSE ANALOGUES AND DEOXYRIBOSE NUCLEOTIDESen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorViazovkina, Ekaterinaen_HK
dc.contributor.inventorDamha, Masad Joseen_HK
dc.contributor.inventorLok, CNen_HK
dc.contributor.inventorParniak, Michael Aen_HK
patents.identifier.applicationCA 20012419563en_HK
patents.description.assigneeUNIV MCGILL [CA]en_HK
patents.description.countryCanadaen_HK
patents.date.publication2002-03-14en_HK
patents.date.application2001-09-04en_HK
patents.date.priority2001-09-04 PCT/CA2001001252en_HK
patents.date.priority2000-09-06 US 09/230414Pen_HK
patents.description.ccCAen_HK
patents.identifier.publicationCA 2419563en_HK
patents.relation.familyAT 293688 (T) 2005-05-15en_HK
patents.relation.familyAU 8944801 (A) 2002-03-22en_HK
patents.relation.familyAU 2001289448 (B2) 2006-03-16en_HK
patents.relation.familyCA 2419563 (A1) 2002-03-14en_HK
patents.relation.familyDE 60110244 (T2) 2006-01-19en_HK
patents.relation.familyEP 1315807 (A2) 2003-06-04en_HK
patents.relation.familyJP 2004507272 (A) 2004-03-11en_HK
patents.relation.familyUS 2004038399 (A1) 2004-02-26en_HK
patents.relation.familyUS 8178348 (B2) 2012-05-15en_HK
patents.relation.familyWO 0220773 (A2) 2002-03-14en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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