Name Card
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Man, Kwan 萬鈞

Title:
Professor

Department:

Professional Qualifications
YearAwarding InstitutionQualification
MBBS
MS
1998The University of Hong KongPhD
Biography
The long-term strategic goal of my research is to improve the outcomes of liver transplantation by reducing the graft injury through integrated basic, clinical and translational studies. I have developed a series of novel animal models to mimic liver graft injury and cancer recurrence. I am first to establish a rat orthotopic liver transplantation model using small-for-size graft in Hong Kong. These models have been extensively introduced into the investigation of liver transplantation. For example, the correlation between transient portal hypertension resulted from excessive portal flow and hepatic sinusoidal damage of small-for-size liver graft was first revealed in animal model we established and the finding was subsequently validated in a series of our clinical studies. The further studies for the mechanism of graft injury and novel treatments were also conducted in animal models we established. We are first to report the significance of small-for-size liver graft injury on tumor recurrence after transplantation in the world and further to explore the molecular mechanisms of inflammatory response in acute phase and tumor invasiveness in late phase. We are also first to uncover the precise mechanism of marginal liver graft injury in our novel rat model of liver transplantation using small-for-size fatty grafts. In parallel, I have focused on the molecular mechanisms involved inflammation and cancer progression, together with the development of novel therapies for cancer metastasis. In addition, I have also established the research platform for in vivo small animal imaging modalities, which are widely applied in various research fields in the Faculty.
I am currently the Regional Associate Editor (Asia) of Transplantation and Associate Editor of Liver Transplantation. I am also the member of the Basic Science Committee of Liver Transplantation Society (ILTS) as well as The Transplantation Society (TTS), Chairperson of ILTS Scholarship Committee, member of ILTS Education Committee, Founder member of Women Leaders in Transplantation (WLIL), International Mentor of WLIL and a Key Opinion Leader of TTS. I have published more than 100 original articles in international journals with H index 29 (total citation >3900). I and my research team have obtained more than 27 international awards including numerous “Rising Star Awards”, “Young Investigator Awards” in annual congress of ILTS, and “Mentee-Mentor Basic Science Awards” In TTS meetings over the past 7 years.
 
 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Qi, X
Li, C
Liu, X
Geng, W
Ling, C
Ma, YY
2012-07-01The Transplantation Society International Basic Science Mentee-Mentor Travel Award (Paper titled "Acute phase graft injury promotes tumor invasiveness through down-regulation of Glutathione Peroxidase 3 (GPx3) after liver transplantation"): The 24th International Congress of The Transplantation Society, Berlin, Germany, 15-19 July 2012
Research Achievement
2007-06-01Rising Star Researcher Award: International Liver Transplantation Society
Research Achievement
2005-07-20Young Investigator Award - "Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation": The 11th Annual Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005
Research Achievement
Li, C
Shao, Y
Liu, X
Ling, C
2010-06-16FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells, myeloid-derived suppressor cells and regulatory T cells (Young Investigator Award): The 16th Annual International Congress of the International Liver Transplantation Society, Hong Kong, 16 - 19 June 2010
Research Achievement
Geng, W
Cheng, Q
Liu, X
2011-06-22Young Investigator Travel Award - The role of interferon-gamma inducible protein 10 (IP10) in early-phase graft injury induced cisplatin resistance after liver transplantation (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011
Research Achievement
Liu, X
Geng, W
Ling, C
Li, C
2010-06-30MicroRNA signatures associated with acute phase small-for size liver graft injury and tumor invasiveness (Young Investigator Award): The 16th International Liver Transplantation Society Congress, Hong Kong, 16-19 June 2010
Research Achievement
2014-07-28International TTS Basic Science Mentor Award: 2014 World Transplant Congress, San Francisco, USA, 26-31 July 2014
Research Achievement
Qi, X
Liu, X
Geng, W
Ling, C
Li, C
2011-06-22Young Investigator Travel Award - The role of glutathione peroxidase 3 (GPx3): bridging liver graft injury and tumor invasiveness after liver transplantation (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011
Research Achievement
Wong, N
Li, C
2012-05-01Acute phase circulating microRNAs predict tumor recurrence and survivals of hepatocellular carcinoma patients after liver transplantation: Young Investigator Award, the 18th Annual International Congress of the International Liver Transplantation Society, San Francisco, California, U.S.A., 16 - 19 May 2012
Research Achievement
2013-12-02自然科學獎一等獎, 國家教育部2013年度高等學校科學研究優秀成果獎(科學技術)
Research Achievement
2013-11-09International TTS Basic Science Mentor Award: XIII TTS Basic Science Symposium, Paris, France, 7-9 November 2013
Research Achievement
2003-06-18Best Oral Presentation Award, FTY720 attenuates ischemia-reperfusion injury in normal and cirrhotic rat liver by down-regulation of Egr-1 and activation of Akt pathway: The 9th Congress of the International Liver Transplantation Society and 13th Congress of the Liver Intensive Care Group of Europe, Barcelona, Spain, 18-21 June 2003
Research Achievement
Ma, YY
Li, C
Law, CFBC
2012-05-012012Young Investigator Travel Award: 18th International Liver Transplantation Society Congress,may 16 - 19, 2012 San Francisco, Californa, USA Novel Mechanism for Tissue Repair of Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells during Liver Regeneration, Liver Transplantation
Research Achievement
Cheung, CKY
2011-06-22Young Investigator Travel Award - Differential replication of hepatitis B virus mutants in recurrent hepatocellular carcinoma after liver transplantation (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011
Research Achievement
Shih, KC
Xiao, J
2007-06-20Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts": The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007
Research Achievement
2005-12-02Distinguished Scientific Award - "Significant activation of cell invasion and migration pathways in small-for-size grafts potentially increase tumor recurrence after LDLT": The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005
Research Achievement
2005-07-01Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation: 11th International Liver Transplantation Society Conference, LA, July 20-23, 2005
Research Achievement
2003-06-09Young Investigator Travel Award, Hepartic ischemia/reperfusion injury on small liver remnant promotes liver tumor growth and metastasis - activation of cell invasion and migration pathways: 10th International Liver Transplantation Society Conference, Kyoto, Japan, 9 - 12 June 2004
Research Achievement
Liu, Y
Cheng, Q
Liu, X
de Villa, MVH
2009-07-08The distinct regeneration pattern of small-for-size fatty liver graft - the significance of aldose reductase signaling on oval cell activation (Travel Award): The 15th Annual International Congress of the International Liver Transplant Society, New York City, New York, U.S.A., 8 - 11 July 2009
Research Achievement
2008-04-12AACR Scholar in Training Award - "Angiopoietin-like protein 4 suppresses liver tumor growth and metastases by inhibition of angiogenesis and cell invasion": The Annual Meeting of the American Association for Cancer Research, San Diego, California, U.S.A., 12 - 16 April 2008
Research Achievement
Li, C
Shao, Y
Ling, C
Liu, X
Ma, YY
Chung, SK
2011-06-11International TTS Basic Science Symposium Mentee/Mentor Travel Award - Aldose reductase accelerates small-for-size fatty liver graft injury (Abstract): XII TTS Basic Science Symposium and II ESOT Basic Science Meeting, Boston, USA, 11-14 June 2011
Research Achievement
2006-05-03Rising Star Research Award - "The significance of graft size on tumor recurrence/metastases after liver transplantation - activation of cell invasion and migration pathways": The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006
Research Achievement
Geng, W
Cheng, Q
Liu, Y
Liu, X
2010-06-16The potential role of early-phase liver graft injury in induction of late-phase chemoresistance after liver transplantation (Young Investigator Award): The 16th Annual International Congress of the International Liver Transplantation Society, Hong Kong, 16 - 19 June 2010
Research Achievement
Li, C
Shao, Y
Ling, C
Liu, X
Ma, YY
Chung, SK
2011-06-22Rising Star Award - Aldose reductase accelerates hepatic ischemia reperfusion injury via IP10/TLR4 signaling (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011
Research Achievement
Liu, X
Cheng, Q
Liu, Y
2010-06-01Epithelial to mesenchymal transition in development of liver fibrosis in small-for-size fatty liver graft (Rising Star Award): The 16th International Liver Transplantation Society Congress, Hong Kong, 16-19 June 2010
Research Achievement
Qi, X
Liu, X
Geng, W
Ling, C
Li, C
2011-06-11International TTS Basic Science Symposium Mentee/Mentor Travel Award - Down-regulation of glutathione peroxidase 3 (GPx3) by acute phase inflammation in small-for-size graft promotes tumor invasiveness after liver transplantation (Abstract): XII TTS Basic Science Symposium and II ESOT Basic Science Meeting, Boston, USA, 11-14 June 2011
Research Achievement
Wang, Y
Wong, G
Irwin, M
2011-06-22Young Investigator Travel Award - Intravenous and intrathecal morphine treatment attenuates hepatic ischemia-reperfusion injury in a rat model (Abstract): The 2011 Joint International Congress of ILTS, ELITA, & LICAGE, Valencia, Spain, 22-25 June 2011
Research Achievement
Ling, C
Liu, X
Li, C
Leung, ACF
2010-06-16Acute phase liver graft injury significantly mobilized circulating endothelial progenitor cells, myeloid-derived suppressor cells and regulatory T cells (Young Investigator Award): The 16th Annual International Congress of the International Liver Transplantation Society, Hong Kong, 16 - 19 June 2010
Research Achievement
2007-12-01Outstanding Poster Presentation Award - "Functional characterization of homeoprotein Six1 in hepatocellular carcinoma": The 12th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 12 - 14 December 2007
Research Achievement
Geng, W
Li, C
Liu, X
2014-12-012014中华医学科技奖一等奖 (活体肝移植的创新性研究), 中华医学会
Research Achievement
Li, C
2015-11-01Mentee and Mentor Travel Award: The 14th Transplantation Science Symposium, Lorne, Australia, 11-13 November 2015
Research Achievement
Qi, X
Shao, Y
Ling, C
Li, C
MA, YY
2015-07-01Young Investigator Award ("Glutathione peroxidase 3 (GPx3) suppressed HCC invasiveness through JNK-cJun-MMP2 signaling pathway - Application of in vivo real-time molecular imaging"): ILTS 21st Annual International Congress, Chicago, USA, 8-11 July 2015
Research Achievement
Yeung, WH
LIU, H
2016-08-01Young Investigator Award (Paper title: Clinical significance of transforming growth factor beta receptor III (TGFβR3) with its suppressive role on tumor associated macrophages in HCC.): The 26th International Congress of The Transplantation Society. Hong Kong, Aug 2016.
Research Achievement
Lam, YF
Li, C
Qi, X
Liu, X
Yeung, WH
LIU, H
LIU, J
2016-08-01Young Investigator Award (Paper title: Up-regulation of GSTA2 at early-phase after liver transplantation increases the risk of late-phase hepatocellular carcinoma recurrence.): The 26th International Congress of The Transplantation Society, Hong Kong, Aug 2016
Research Achievement
LIU, H
Li, C
Yeung, WH
Liu, X
Qi, X
LIU, J
MA, YY
2015-11-01Travel Grant Award ("NLRP3 inflammasome initiated liver graft injury through telomere-independent repressor activator protein1 (RAP1) / keratinocyte chemoattractant (KC) axis"): Transplantation Science Symposium of The Transplantation Society, Lorne, Australia, 11-13 November 2015
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
Since 2003Full memberInternational Liver Transplantation Society
Since 2012Committee memberBasic Science Committee of The Transplantation Society (TTS)
Since 2005International memberAmerican Society of Transplantation
Since 2010Founder member and international turorWorman in Transplantation of TTS
Since 2007Committee MemberBasic Science Committee of ILTS
Since 2003Full memberThe Transplantation society
Since 2005Active memberCentre for Cancer Research, LKS Facuty of Medicine, HKU
Since 2009Founder MemberFounder member of Women Leaders in Transplantation
Since 2007Committee MemberScholar review Committee of ILTS
Since 2011Committee memberEducation Committee of ILTS
Since 2010ChairScholarship Commmittee of ILTS
Since 2006Active memberAmerican Assoiation of Cancer Research
Since 2007MemberInternational Liver Cancer Association
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