File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s00383-022-05137-8
- Scopus: eid_2-s2.0-85129565243
- PMID: 35523886
- WOS: WOS:000791652800001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Long-term follow-up of biliary atresia using liver transient elastography
Title | Long-term follow-up of biliary atresia using liver transient elastography |
---|---|
Authors | |
Keywords | Biliary atresia Liver fibrosis Liver transient elastography Portal hypertension |
Issue Date | 2022 |
Citation | Pediatric Surgery International, 2022, v. 38, n. 7, p. 1013-1018 How to Cite? |
Abstract | Objective: Liver transient elastography (TE) using FibroScan® has gained popularity as a non-invasive technique to assess hepatic fibrosis by measuring liver stiffness. This study focused on biliary atresia patients post Kasai operation for more than 10 years to prospectively correlate the hepatic fibrosis score to the biochemical changes of liver fibrosis and clinical development of portal hypertensive complications. Methods: TE was performed in 37 patients who had biliary atresia post Kasai operation done at median age of 60 days. Biochemical indices of liver fibrosis including aspartate aminotransferase/platelet ratio index (APRI) and Fibrosis-4 (FIB-4) score based on age, platelet count, alanine aminotransferase and aspartate aminotransferase level were calculated at the time of TE. Platelet count, spleen size, varices, ascites and hepatic encephalopathy were evaluated as clinical markers of portal hypertension. Results: There were 22 female and 15 male with TE done at median age of 17.0 years. Median FibroScan® fibrosis score was 11.4. Fibrosis score of 6.8 kilopascal (kPa) was taken as the upper reference limit of normal. Nine patients (24%) had normal fibrosis score. Score above or equal to 6.8 kPa was significantly associated with lower platelet level (p = 0.001), higher INR (p = 0.043), higher APRI (p = 0.021), higher FIB-4 score (p = 0.013), and larger splenic diameter (p = 0.004). Higher FibroScan® fibrosis score was also significantly associated with portal hypertensive complications (p = 0.001). Conclusions: The FibroScan® fibrosis score correlated well with the biochemical changes of liver fibrosis and development of portal hypertensive complications clinically. Screening of portal hypertensive complications such as varices is recommended for patients with raised fibrosis score upon long-term follow-up. Level of evidence: Level III, retrospective comparative study. |
Persistent Identifier | http://hdl.handle.net/10722/341356 |
ISSN | 2023 Impact Factor: 1.5 2023 SCImago Journal Rankings: 0.548 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeung, Fanny | - |
dc.contributor.author | Fung, Adrian C.H. | - |
dc.contributor.author | Chung, Patrick H.Y. | - |
dc.contributor.author | Chu, Y. Y. | - |
dc.contributor.author | Seto, W. K. | - |
dc.contributor.author | Wong, Kenneth K.Y. | - |
dc.date.accessioned | 2024-03-13T08:42:10Z | - |
dc.date.available | 2024-03-13T08:42:10Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Pediatric Surgery International, 2022, v. 38, n. 7, p. 1013-1018 | - |
dc.identifier.issn | 0179-0358 | - |
dc.identifier.uri | http://hdl.handle.net/10722/341356 | - |
dc.description.abstract | Objective: Liver transient elastography (TE) using FibroScan® has gained popularity as a non-invasive technique to assess hepatic fibrosis by measuring liver stiffness. This study focused on biliary atresia patients post Kasai operation for more than 10 years to prospectively correlate the hepatic fibrosis score to the biochemical changes of liver fibrosis and clinical development of portal hypertensive complications. Methods: TE was performed in 37 patients who had biliary atresia post Kasai operation done at median age of 60 days. Biochemical indices of liver fibrosis including aspartate aminotransferase/platelet ratio index (APRI) and Fibrosis-4 (FIB-4) score based on age, platelet count, alanine aminotransferase and aspartate aminotransferase level were calculated at the time of TE. Platelet count, spleen size, varices, ascites and hepatic encephalopathy were evaluated as clinical markers of portal hypertension. Results: There were 22 female and 15 male with TE done at median age of 17.0 years. Median FibroScan® fibrosis score was 11.4. Fibrosis score of 6.8 kilopascal (kPa) was taken as the upper reference limit of normal. Nine patients (24%) had normal fibrosis score. Score above or equal to 6.8 kPa was significantly associated with lower platelet level (p = 0.001), higher INR (p = 0.043), higher APRI (p = 0.021), higher FIB-4 score (p = 0.013), and larger splenic diameter (p = 0.004). Higher FibroScan® fibrosis score was also significantly associated with portal hypertensive complications (p = 0.001). Conclusions: The FibroScan® fibrosis score correlated well with the biochemical changes of liver fibrosis and development of portal hypertensive complications clinically. Screening of portal hypertensive complications such as varices is recommended for patients with raised fibrosis score upon long-term follow-up. Level of evidence: Level III, retrospective comparative study. | - |
dc.language | eng | - |
dc.relation.ispartof | Pediatric Surgery International | - |
dc.subject | Biliary atresia | - |
dc.subject | Liver fibrosis | - |
dc.subject | Liver transient elastography | - |
dc.subject | Portal hypertension | - |
dc.title | Long-term follow-up of biliary atresia using liver transient elastography | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00383-022-05137-8 | - |
dc.identifier.pmid | 35523886 | - |
dc.identifier.scopus | eid_2-s2.0-85129565243 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1013 | - |
dc.identifier.epage | 1018 | - |
dc.identifier.eissn | 1437-9813 | - |
dc.identifier.isi | WOS:000791652800001 | - |